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{{STRUCTURE_3pki|  PDB=3pki  |  SCENE=  }}
==Human SIRT6 crystal structure in complex with ADP ribose==
===Human SIRT6 crystal structure in complex with ADP ribose===
<StructureSection load='3pki' size='340' side='right' caption='[[3pki]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
{{ABSTRACT_PUBMED_021362626}}
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3pki]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PKI FirstGlance]. <br>
==Function==
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[http://www.uniprot.org/uniprot/SIRT6_HUMAN SIRT6_HUMAN]] NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.<ref>PMID:18337721</ref> <ref>PMID:19135889</ref> <ref>PMID:19625767</ref> <ref>PMID:20829486</ref> <ref>PMID:21362626</ref>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3pkj|3pkj]]</td></tr>
 
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIRT6, SIR2L6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pki OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pki RCSB], [http://www.ebi.ac.uk/pdbsum/3pki PDBsum]</span></td></tr>
[[3pki]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKI OCA].  
</table>
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:021362626</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H]]
[[Category: Bochkarev, A.]]
[[Category: Bochkarev, A]]
[[Category: Bountra, C.]]
[[Category: Bountra, C]]
[[Category: Dong, A.]]
[[Category: Dong, A]]
[[Category: Edwards, A M.]]
[[Category: Edwards, A M]]
[[Category: Loppnau, P.]]
[[Category: Loppnau, P]]
[[Category: Min, J.]]
[[Category: Min, J]]
[[Category: Pan, P W.]]
[[Category: Pan, P W]]
[[Category: Qiu, W.]]
[[Category: Qiu, W]]
[[Category: Ravichandran, M.]]
[[Category: Ravichandran, M]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Structural genomic]]
[[Category: Wang, J.]]
[[Category: Wang, J]]
[[Category: Weigelt, J.]]
[[Category: Weigelt, J]]
[[Category: Adp ribose]]
[[Category: Adp ribose]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Sgc]]
[[Category: Sgc]]
[[Category: Sirt6]]
[[Category: Sirt6]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]

Revision as of 13:15, 19 December 2014

Human SIRT6 crystal structure in complex with ADP riboseHuman SIRT6 crystal structure in complex with ADP ribose

Structural highlights

3pki is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , ,
Gene:SIRT6, SIR2L6 (Homo sapiens)
Resources:FirstGlance, OCA, RCSB, PDBsum

3pki, resolution 2.04Å

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