3jv0: Difference between revisions

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{{STRUCTURE_3jv0|  PDB=3jv0  |  SCENE=  }}
==Crystal structure of a mutant of RelB dimerization domain(M6)==
===Crystal structure of a mutant of RelB dimerization domain(M6)===
<StructureSection load='3jv0' size='340' side='right' caption='[[3jv0]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
 
== Structural highlights ==
==Function==
<table><tr><td colspan='2'>[[3jv0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JV0 FirstGlance]. <br>
[[http://www.uniprot.org/uniprot/RELB_MOUSE RELB_MOUSE]] NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.<ref>PMID:22565310</ref>  
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zk9|1zk9]], [[3jtc|3jtc]], [[3juz|3juz]], [[3jv4|3jv4]], [[3jv5|3jv5]], [[3jv6|3jv6]]</td></tr>
 
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RelB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
==About this Structure==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jv0 RCSB], [http://www.ebi.ac.uk/pdbsum/3jv0 PDBsum]</span></td></tr>
[[3jv0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JV0 OCA].  
</table>
 
__TOC__
==Reference==
</StructureSection>
<references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Ghosh, G.]]
[[Category: Ghosh, G]]
[[Category: Huang, D B.]]
[[Category: Huang, D B]]
[[Category: Vu, D.]]
[[Category: Vu, D]]
[[Category: Activator]]
[[Category: Activator]]
[[Category: Intertwined homodimer]]
[[Category: Intertwined homodimer]]

Revision as of 19:50, 18 December 2014

Crystal structure of a mutant of RelB dimerization domain(M6)Crystal structure of a mutant of RelB dimerization domain(M6)

Structural highlights

3jv0 is a 1 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:RelB (Mus musculus)
Resources:FirstGlance, OCA, RCSB, PDBsum

3jv0, resolution 2.65Å

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OCA
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