1qhv: Difference between revisions
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'''HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD''' | {{Structure | ||
|PDB= 1qhv |SIZE=350|CAPTION= <scene name='initialview01'>1qhv</scene>, resolution 1.51Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | |||
|ACTIVITY= | |||
|GENE= LOCUS AD2H2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10515 Human adenovirus 2]) | |||
}} | |||
'''HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1QHV is a [ | 1QHV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_2 Human adenovirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QHV OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution., van Raaij MJ, Louis N, Chroboczek J, Cusack S, Virology. 1999 Sep 30;262(2):333-43. PMID:[http:// | Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution., van Raaij MJ, Louis N, Chroboczek J, Cusack S, Virology. 1999 Sep 30;262(2):333-43. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10502512 10502512] | ||
[[Category: Human adenovirus 2]] | [[Category: Human adenovirus 2]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: receptor binding]] | [[Category: receptor binding]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:37:41 2008'' | ||
Revision as of 14:37, 20 March 2008
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| , resolution 1.51Å | |||||||
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| Ligands: | |||||||
| Gene: | LOCUS AD2H2 (Human adenovirus 2) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD
OverviewOverview
Adenovirus binds to its receptor via the head domain of its fiber protein. We have crystallized the adenovirus serotype 2 (subgroup C) receptor binding domain and solved the structure at 1.5 A resolution by the molecular replacement technique using the known adenovirus type 5 head structure. Included in the high-resolution model are 306 water molecules, five alternative side chain conformations, and individual anisotropic temperature factors for each atom. The overall structure of the serotype 2 head is very similar to its serotype 5 homologue, apart from differences in some of the flexible loops. All but subgroup B adenoviruses are believed to use the recently identified protein CAR (Coxsackievirus and adenovirus receptor) as receptor. By comparison of the two structures and sequence alignment of CAR binding and non-CAR binding serotype fiber heads, we discuss possible receptor binding sites and propose a receptor binding site in a crevice between two monomers on the side of the trimer. The structural basis of the extraordinary stability of the fiber head trimer is also discussed.
About this StructureAbout this Structure
1QHV is a Single protein structure of sequence from Human adenovirus 2. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution., van Raaij MJ, Louis N, Chroboczek J, Cusack S, Virology. 1999 Sep 30;262(2):333-43. PMID:10502512
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