3lm5: Difference between revisions

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-{{STRUCTURE_3lm5|  PDB=3lm5  |  SCENE=  }}
+==Crystal Structure of human Serine/Threonine Kinase 17B (STK17B) in complex with Quercetin==
-===Crystal Structure of human Serine/Threonine Kinase 17B (STK17B) in complex with Quercetin===
+<StructureSection load='3lm5' size='340' side='right' caption='[[3lm5]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3lm5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LM5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LM5 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QUE:3,5,7,3,4-PENTAHYDROXYFLAVONE'>QUE</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3eha|3eha]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DRAK2, STK17B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lm5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lm5 RCSB], [http://www.ebi.ac.uk/pdbsum/3lm5 PDBsum]</span></td></tr>
+</table>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lm/3lm5_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+<div style="clear:both"></div>
-==Function==
+==See Also==
-[[http://www.uniprot.org/uniprot/ST17B_HUMAN ST17B_HUMAN]] Phosphorylates myosin light chains (By similarity). Acts as a positive regulator of apoptosis.<ref>PMID:9786912</ref>
+*[[Serine/threonine protein kinase|Serine/threonine protein kinase]]
+__TOC__
-==About this Structure==
+</StructureSection>
-[[3lm5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LM5 OCA].
-==Reference==
-<references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Non-specific serine/threonine protein kinase]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith, C H]]
-[[Category: Bountra, C.]]
+[[Category: Bountra, C]]
-[[Category: Carpenter, L.]]
+[[Category: Carpenter, L]]
-[[Category: Chaikuad, A.]]
+[[Category: Chaikuad, A]]
-[[Category: Delft, F von.]]
+[[Category: Delft, F von]]
-[[Category: Edwards, A.]]
+[[Category: Edwards, A]]
-[[Category: Fedorov, O.]]
+[[Category: Fedorov, O]]
-[[Category: Filippakopoulos, P.]]
+[[Category: Filippakopoulos, P]]
-[[Category: Hapka, E.]]
+[[Category: Hapka, E]]
-[[Category: Knapp, S.]]
+[[Category: Knapp, S]]
-[[Category: Phillips, C.]]
+[[Category: Phillips, C]]
-[[Category: Pike, A C.W.]]
+[[Category: Pike, A C.W]]
-[[Category: Rellos, P.]]
+[[Category: Rellos, P]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Structural genomic]]
-[[Category: Soundararajan, M.]]
+[[Category: Soundararajan, M]]
-[[Category: Ugochukwu, E.]]
+[[Category: Ugochukwu, E]]
-[[Category: Vollmar, M.]]
+[[Category: Vollmar, M]]
-[[Category: Wang, J.]]
+[[Category: Wang, J]]
-[[Category: Weigelt, J.]]
+[[Category: Weigelt, J]]
 [[Category: Apoptosis]]
 [[Category: Atp-binding]]
@@ Line 44: / Line 58: @@
 [[Category: Sgc]]
 [[Category: Stk17b]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
 [[Category: Transferase]]