1gws: Difference between revisions
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==Overview== | ==Overview== | ||
Sulfate-reducing bacteria contain a variety of multi-heme c-type, cytochromes. The cytochrome of highest molecular weight (Hmc) contains 16, heme groups and is part of a transmembrane complex involved in the sulfate, respiration pathway. We present the 2.42 A resolution crystal structure of, the Desulfovibrio vulgaris Hildenborough cytochrome Hmc and a structural, model of the complex with its physiological electron transfer partner, cytochrome c(3), obtained by NMR restrained soft-docking calculations. The, Hmc is composed of three domains, which exist independently in different, sulfate-reducing species, namely cytochrome c(3), cytochrome c(7), and, Hcc. The complex involves the last heme at the C-terminal region of the, V-shaped Hmc and heme 4 of cytochrome c(3), and represents an . | Sulfate-reducing bacteria contain a variety of multi-heme c-type, cytochromes. The cytochrome of highest molecular weight (Hmc) contains 16, heme groups and is part of a transmembrane complex involved in the sulfate, respiration pathway. We present the 2.42 A resolution crystal structure of, the Desulfovibrio vulgaris Hildenborough cytochrome Hmc and a structural, model of the complex with its physiological electron transfer partner, cytochrome c(3), obtained by NMR restrained soft-docking calculations. The, Hmc is composed of three domains, which exist independently in different, sulfate-reducing species, namely cytochrome c(3), cytochrome c(7), and, Hcc. The complex involves the last heme at the C-terminal region of the, V-shaped Hmc and heme 4 of cytochrome c(3), and represents an example for, specific cytochrome-cytochrome interaction. | ||
==About this Structure== | ==About this Structure== | ||
1GWS is a | 1GWS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Desulfovibrio_vulgaris Desulfovibrio vulgaris] with HEM and HEC as [http://en.wikipedia.org/wiki/ligands ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GWS OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: sulfate reducing bacteria]] | [[Category: sulfate reducing bacteria]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 12:36:16 2007'' | ||