3nea: Difference between revisions

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-{{STRUCTURE_3nea|  PDB=3nea  |  SCENE=  }}
+==Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis==
-===Crystal Structure of Peptidyl-tRNA hydrolase from Francisella tularensis===
+<StructureSection load='3nea' size='340' side='right' caption='[[3nea]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-{{ABSTRACT_PUBMED_21505237}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3nea]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis Francisella tularensis subsp. tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NEA FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FTT_0680c, pth ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=119856 Francisella tularensis subsp. tularensis])</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aminoacyl-tRNA_hydrolase Aminoacyl-tRNA hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.29 3.1.1.29] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nea OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nea RCSB], [http://www.ebi.ac.uk/pdbsum/3nea PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The rational design of novel antibiotics for bacteria involves the identification of inhibitors for enzymes involved in essential biochemical pathways in cells. In this study, the cloning, expression, purification, crystallization and structure of the enzyme peptidyl-tRNA hydrolase from Francisella tularensis, the causative agent of tularemia, was performed. The structure of F. tularensis peptidyl-tRNA hydrolase is comparable to those of other bacterial peptidyl-tRNA hydrolases, with most residues in the active site conserved amongst the family. The resultant reagents, structural data and analyses provide essential information for the structure-based design of novel inhibitors for this class of proteins.
-==Function==
+Structure of Francisella tularensis peptidyl-tRNA hydrolase.,Clarke TE, Romanov V, Lam R, Gothe SA, Peddi SR, Razumova EB, Lipman RS, Branstrom AA, Chirgadze NY Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt, 4):446-9. Epub 2011 Mar 26. PMID:21505237<ref>PMID:21505237</ref>
-[[http://www.uniprot.org/uniprot/PTH_FRATT PTH_FRATT]] The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity).
-==About this Structure==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[3nea]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis Francisella tularensis subsp. tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NEA OCA].
+</div>
-==Reference==
+==See Also==
-<ref group="xtra">PMID:021505237</ref><references group="xtra"/><references/>
+*[[Peptidyl-tRNA hydrolase|Peptidyl-tRNA hydrolase]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Aminoacyl-tRNA hydrolase]]
 [[Category: Francisella tularensis subsp. tularensis]]
-[[Category: Branstrom, A A.]]
+[[Category: Branstrom, A A]]
-[[Category: Chirgadze, N Y.]]
+[[Category: Chirgadze, N Y]]
-[[Category: Gothe, S A.]]
+[[Category: Gothe, S A]]
-[[Category: Lam, R.]]
+[[Category: Lam, R]]
-[[Category: Lipman, R S.]]
+[[Category: Lipman, R S]]
-[[Category: McGrath, T E.]]
+[[Category: McGrath, T E]]
-[[Category: Peddi, S R.]]
+[[Category: Peddi, S R]]
-[[Category: Razumova, E.]]
+[[Category: Razumova, E]]
-[[Category: Romanov, V.]]
+[[Category: Romanov, V]]
 [[Category: Hydrolase]]
 [[Category: Peptidyl-trna]]