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{{STRUCTURE_3b0f|  PDB=3b0f  |  SCENE=  }}
==Crystal structure of the UBA domain of p62 and its interaction with ubiquitin==
===Crystal structure of the UBA domain of p62 and its interaction with ubiquitin===
<StructureSection load='3b0f' size='340' side='right' caption='[[3b0f]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
{{ABSTRACT_PUBMED_021715324}}
== Structural highlights ==
<table><tr><td colspan='2'>[[3b0f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3B0F FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2rru|2rru]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Sqstm1, A170, STAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b0f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b0f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3b0f RCSB], [http://www.ebi.ac.uk/pdbsum/3b0f PDBsum]</span></td></tr>
</table>


==Function==
==See Also==
[[http://www.uniprot.org/uniprot/SQSTM_MOUSE SQSTM_MOUSE]] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.<ref>PMID:14960283</ref> <ref>PMID:18382763</ref> 
*[[Sequestosome|Sequestosome]]
 
__TOC__
==About this Structure==
</StructureSection>
[[3b0f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B0F OCA].
 
==Reference==
<references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Arita, K.]]
[[Category: Arita, K]]
[[Category: Hasegawa, J.]]
[[Category: Hasegawa, J]]
[[Category: Isogai, S.]]
[[Category: Isogai, S]]
[[Category: Komatsu, M.]]
[[Category: Komatsu, M]]
[[Category: Morimoto, D.]]
[[Category: Morimoto, D]]
[[Category: Shirakawa, M.]]
[[Category: Shirakawa, M]]
[[Category: Sou, Y.]]
[[Category: Sou, Y]]
[[Category: Tanaka, K.]]
[[Category: Tanaka, K]]
[[Category: Tenno, T.]]
[[Category: Tenno, T]]
[[Category: Tochio, H.]]
[[Category: Tochio, H]]
[[Category: Unzai, S.]]
[[Category: Unzai, S]]
[[Category: Autophagy]]
[[Category: Autophagy]]
[[Category: Protein binding]]
[[Category: Protein binding]]
[[Category: Ubiquitin]]
[[Category: Ubiquitin]]

Revision as of 17:24, 18 December 2014

Crystal structure of the UBA domain of p62 and its interaction with ubiquitinCrystal structure of the UBA domain of p62 and its interaction with ubiquitin

Structural highlights

3b0f is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:Sqstm1, A170, STAP (Mus musculus)
Resources:FirstGlance, OCA, RCSB, PDBsum

See Also

3b0f, resolution 1.40Å

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