1prq: Difference between revisions
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[[Image:1prq.gif|left|200px]] | [[Image:1prq.gif|left|200px]] | ||
'''ACANTHAMOEBA CASTELLANII PROFILIN IA''' | {{Structure | ||
|PDB= 1prq |SIZE=350|CAPTION= <scene name='initialview01'>1prq</scene>, resolution 2.5Å | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''ACANTHAMOEBA CASTELLANII PROFILIN IA''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1PRQ is a [ | 1PRQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Acanthamoeba_castellanii Acanthamoeba castellanii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PRQ OCA]. | ||
==Reference== | ==Reference== | ||
Crystal packing induces a conformational change in profilin-I from Acanthamoeba castellanii., Liu S, Fedorov AA, Pollard TD, Lattman EE, Almo SC, Magnus KA, J Struct Biol. 1998 Sep;123(1):22-9. PMID:[http:// | Crystal packing induces a conformational change in profilin-I from Acanthamoeba castellanii., Liu S, Fedorov AA, Pollard TD, Lattman EE, Almo SC, Magnus KA, J Struct Biol. 1998 Sep;123(1):22-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9774541 9774541] | ||
[[Category: Acanthamoeba castellanii]] | [[Category: Acanthamoeba castellanii]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: actin-binding protein]] | [[Category: actin-binding protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:28:09 2008'' | ||
Revision as of 14:28, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
ACANTHAMOEBA CASTELLANII PROFILIN IA
OverviewOverview
Profilin-I from Acanthamoeba castellanii is a 13-kDa protein that binds actin and poly-l-proline. The native protein has been crystallized in two different but closely related forms. The second form proved more amenable to three-dimensional structural determination using heavy-atom isomorphous methods to obtain crystallographic phase information. We used the second crystal structure as a test molecule in the molecular replacement procedure to determine the structure of the first crystal form of profilin-I. More residues participate in crystal lattice contacts in the first crystal form than in the second. The two crystal forms differ significantly in the C-terminal helix that interacts with actin and in the loop preceding this helix. Coordinates of some main chain atoms here differ by about 1.0 A, and side chain atoms differ by more than 2.0 A.
About this StructureAbout this Structure
1PRQ is a Single protein structure of sequence from Acanthamoeba castellanii. Full crystallographic information is available from OCA.
ReferenceReference
Crystal packing induces a conformational change in profilin-I from Acanthamoeba castellanii., Liu S, Fedorov AA, Pollard TD, Lattman EE, Almo SC, Magnus KA, J Struct Biol. 1998 Sep;123(1):22-9. PMID:9774541
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