2x44: Difference between revisions

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{{STRUCTURE_2x44|  PDB=2x44  |  SCENE=  }}
==STRUCTURE OF A STRAND-SWAPPED DIMERIC FORM OF CTLA-4==
===STRUCTURE OF A STRAND-SWAPPED DIMERIC FORM OF CTLA-4===
<StructureSection load='2x44' size='340' side='right' caption='[[2x44]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
{{ABSTRACT_PUBMED_20394753}}
== Structural highlights ==
<table><tr><td colspan='2'>[[2x44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X44 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X44 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ah1|1ah1]], [[1h6e|1h6e]], [[1i8l|1i8l]], [[1i85|1i85]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x44 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x44 RCSB], [http://www.ebi.ac.uk/pdbsum/2x44 PDBsum]</span></td></tr>
</table>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/2x44_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We present the crystal structure of an immunoglobulin light-chain-like domain, CTLA-4, as a strand-swapped dimer displaying cis-trans proline isomerisation and native-like hydrogen bonding. We also show that CTLA-4 can form amyloid-like fibres and amorphous deposits explainable by the same strand swapping. Our results suggest a molecular basis for the pathological aggregation of immunoglobulin domains and why amyloid-like fibres are more often composed of homologous rather than heterologous subunits.


==About this Structure==
Domain metastability: a molecular basis for immunoglobulin deposition?,Sonnen AF, Yu C, Evans EJ, Stuart DI, Davis SJ, Gilbert RJ J Mol Biol. 2010 Jun 4;399(2):207-13. Epub 2010 Apr 13. PMID:20394753<ref>PMID:20394753</ref>
[[2x44]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X44 OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<ref group="xtra">PMID:020394753</ref><references group="xtra"/><references/>
</div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Davis, S J.]]
[[Category: Davis, S J]]
[[Category: Evans, E J.]]
[[Category: Evans, E J]]
[[Category: Gilbert, R J.C.]]
[[Category: Gilbert, R J.C]]
[[Category: Sonnen, A F.P.]]
[[Category: Sonnen, A F.P]]
[[Category: Stuart, D I.]]
[[Category: Stuart, D I]]
[[Category: Yu, C.]]
[[Category: Yu, C]]
[[Category: Amyloidogenic]]
[[Category: Amyloidogenic]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]

Revision as of 14:15, 18 December 2014

STRUCTURE OF A STRAND-SWAPPED DIMERIC FORM OF CTLA-4STRUCTURE OF A STRAND-SWAPPED DIMERIC FORM OF CTLA-4

Structural highlights

2x44 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:FirstGlance, OCA, RCSB, PDBsum

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

We present the crystal structure of an immunoglobulin light-chain-like domain, CTLA-4, as a strand-swapped dimer displaying cis-trans proline isomerisation and native-like hydrogen bonding. We also show that CTLA-4 can form amyloid-like fibres and amorphous deposits explainable by the same strand swapping. Our results suggest a molecular basis for the pathological aggregation of immunoglobulin domains and why amyloid-like fibres are more often composed of homologous rather than heterologous subunits.

Domain metastability: a molecular basis for immunoglobulin deposition?,Sonnen AF, Yu C, Evans EJ, Stuart DI, Davis SJ, Gilbert RJ J Mol Biol. 2010 Jun 4;399(2):207-13. Epub 2010 Apr 13. PMID:20394753[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. ↑ Sonnen AF, Yu C, Evans EJ, Stuart DI, Davis SJ, Gilbert RJ. Domain metastability: a molecular basis for immunoglobulin deposition? J Mol Biol. 2010 Jun 4;399(2):207-13. Epub 2010 Apr 13. PMID:20394753 doi:10.1016/j.jmb.2010.04.011

2x44, resolution 2.60Å

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