1cwi: Difference between revisions
No edit summary |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
1CWI is a | 1CWI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] Structure known Active Site: BIN. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CWI OCA]. | ||
==Reference== | ==Reference== | ||
| Line 21: | Line 21: | ||
[[Category: complex (isomerase/immunosuppressant)]] | [[Category: complex (isomerase/immunosuppressant)]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 12:32:30 2007'' | ||
Revision as of 13:27, 5 November 2007
|
HUMAN CYCLOPHILIN A COMPLEXED WITH 2-VAL 3-(N-METHYL)-D-ALANINE CYCLOSPORIN
OverviewOverview
Eight new X-ray structures of different cyclophilin, A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide, a useful structural database for the analysis of protein-ligand, interactions. The effect of small chemical differences on protein-ligand, hydrogen-bonding, van der Waals interactions and water structure is, presented.
About this StructureAbout this Structure
1CWI is a Single protein structure of sequence from Homo sapiens. Active as Peptidylprolyl isomerase, with EC number 5.2.1.8 Structure known Active Site: BIN. Full crystallographic information is available from OCA.
ReferenceReference
X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A., Kallen J, Mikol V, Taylor P, Walkinshaw MD, J Mol Biol. 1998 Oct 23;283(2):435-49. PMID:9769216
Page seeded by OCA on Mon Nov 5 12:32:30 2007