4abl: Difference between revisions

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-{{STRUCTURE_4abl|  PDB=4abl  |  SCENE=  }}
+==HUMAN PARP14 (ARTD8, BAL2) - MACRO DOMAIN 3==
-===HUMAN PARP14 (ARTD8, BAL2) - MACRO DOMAIN 3===
+<StructureSection load='4abl' size='340' side='right' caption='[[4abl]], [[Resolution|resolution]] 1.15&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4abl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ABL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ABL FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4abk|4abk]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4abl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4abl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4abl RCSB], [http://www.ebi.ac.uk/pdbsum/4abl PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+ADP-ribosyltransferases (ARTs) catalyze the transfer of ADP-ribose from NAD onto substrates. Some ARTs generate in an iterative process ADP-ribose polymers that serve as adaptors for distinct protein domains. Other ARTs, exemplified by ARTD10, function as mono-ADP-ribosyltransferases, but it has been unclear whether this modification occurs in cells and how it is read. We observed that ARTD10 colocalized with ARTD8 and defined its macrodomains 2 and 3 as readers of mono-ADP-ribosylation both in vitro and in cells. The crystal structures of these two ARTD8 macrodomains and isothermal titration calorimetry confirmed their interaction with ADP-ribose. These macrodomains recognized mono-ADP-ribosylated ARTD10, but not poly-ADP-ribosylated ARTD1. This distinguished them from the macrodomain of macroH2A1.1, which interacted with poly- but not mono-ADP-ribosylated substrates. Moreover, Ran, an ARTD10 substrate, was also read by ARTD8 macrodomains. This identifies readers of mono-ADP-ribosylated proteins, defines their structures, and demonstrates the presence of this modification in cells.
-==About this Structure==
+Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains.,Forst AH, Karlberg T, Herzog N, Thorsell AG, Gross A, Feijs KL, Verheugd P, Kursula P, Nijmeijer B, Kremmer E, Kleine H, Ladurner AG, Schuler H, Luscher B Structure. 2013 Mar 5;21(3):462-75. doi: 10.1016/j.str.2012.12.019. PMID:23473667<ref>PMID:23473667</ref>
-[[4abl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ABL OCA].
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
 ==See Also==
 *[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]]
-[[Category: Homo sapiens]]
+== References ==
-[[Category: Arrowsmith, C H.]]
+<references/>
-[[Category: Bountra, C.]]
+__TOC__
-[[Category: Edwards, A M.]]
+</StructureSection>
-[[Category: Ekblad, T.]]
+[[Category: Human]]
-[[Category: Karlberg, T.]]
+[[Category: Arrowsmith, C H]]
-[[Category: Moche, M.]]
+[[Category: Bountra, C]]
-[[Category: Schuler, H.]]
+[[Category: Edwards, A M]]
-[[Category: Thorsell, A G.]]
+[[Category: Ekblad, T]]
-[[Category: Weigelt, J.]]
+[[Category: Karlberg, T]]
+[[Category: Moche, M]]
+[[Category: Schuler, H]]
+[[Category: Thorsell, A G]]
+[[Category: Weigelt, J]]
 [[Category: Parp14]]
 [[Category: Transferase]]