2gtt: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{Large structure}}
+==Crystal structure of the rabies virus nucleoprotein-RNA complex==
-{{STRUCTURE_2gtt|  PDB=2gtt  |  SCENE=  }}
+<StructureSection load='2gtt' size='340' side='right' caption='[[2gtt]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
-===Crystal structure of the rabies virus nucleoprotein-RNA complex===
+== Structural highlights ==
-{{ABSTRACT_PUBMED_16778023}}
+<table><tr><td colspan='2'>[[2gtt]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Rabies_virus Rabies virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GTT FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gtt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gtt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2gtt RCSB], [http://www.ebi.ac.uk/pdbsum/2gtt PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Negative-strand RNA viruses condense their genome into a helical nucleoprotein-RNA complex, the nucleocapsid, which is packed into virions and serves as a template for the RNA-dependent RNA polymerase complex. The crystal structure of a recombinant rabies virus nucleoprotein-RNA complex, organized in an undecameric ring, has been determined at 3.5 angstrom resolution. Polymerization of the nucleoprotein is achieved by domain exchange between protomers, with flexible hinges allowing nucleocapsid formation. The two core domains of the nucleoprotein clamp around the RNA at their interface and shield it from the environment. RNA sequestering by nucleoproteins is likely a common mechanism used by negative-strand RNA viruses to protect their genomes from the innate immune response directed against viral RNA in human host cells at certain stages of an infectious cycle.
-==About this Structure==
+Crystal structure of the rabies virus nucleoprotein-RNA complex.,Albertini AA, Wernimont AK, Muziol T, Ravelli RB, Clapier CR, Schoehn G, Weissenhorn W, Ruigrok RW Science. 2006 Jul 21;313(5785):360-3. Epub 2006 Jun 15. PMID:16778023<ref>PMID:16778023</ref>
-[[2gtt]] is a 24 chain structure with sequence from [http://en.wikipedia.org/wiki/Rabies_virus Rabies virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GTT OCA].
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
 ==See Also==
 *[[Nucleoprotein|Nucleoprotein]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:016778023</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Rabies virus]]
-[[Category: Albertini, A A.V.]]
+[[Category: Albertini, A A.V]]
-[[Category: Muziol, T.]]
+[[Category: Muziol, T]]
-[[Category: Ravelli, R B.G.]]
+[[Category: Ravelli, R B.G]]
-[[Category: Ruigrok, R W.H.]]
+[[Category: Ruigrok, R W.H]]
-[[Category: Weissenhorn, W.]]
+[[Category: Weissenhorn, W]]
-[[Category: Wernimont, A K.]]
+[[Category: Wernimont, A K]]
 [[Category: Nucleoprotein]]
 [[Category: Protein-rna complex]]
-[[Category: Rabies virus]]
 [[Category: Rna binding protein]]
 [[Category: Viral protein]]