1lgl: Difference between revisions

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-{{STRUCTURE_1lgl|  PDB=1lgl  |  SCENE=  }}
+==Solution structure of HERG-specific scorpion toxin BeKm-1==
-===Solution structure of HERG-specific scorpion toxin BeKm-1===
+<StructureSection load='1lgl' size='340' side='right' caption='[[1lgl]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
-{{ABSTRACT_PUBMED_12151390}}
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1lgl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesobuthus_eupeus Mesobuthus eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LGL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LGL FirstGlance]. <br>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lgl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1lgl RCSB], [http://www.ebi.ac.uk/pdbsum/1lgl PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The scorpion toxin BeKm-1 is unique among a variety of known short scorpion toxins affecting potassium channels in its selective action on ether-a-go-go-related gene (ERG)-type channels. BeKm-1 shares the common molecular scaffold with other short scorpion toxins. The toxin spatial structure resolved by NMR consists of a short alpha-helix and a triple-stranded antiparallel beta-sheet. By toxin mutagenesis study we identified the residues that are important for the binding of BeKm-1 to the human ERG K+ (HERG) channel. The most critical residues (Tyr-11, Lys-18, Arg-20, Lys-23) are located in the alpha-helix and following loop whereas the "traditional" functional site of other short scorpion toxins is formed by residues from the beta-sheet. Thus the unique location of the binding site of BeKm-1 provides its specificity toward the HERG channel.
-==About this Structure==
+New binding site on common molecular scaffold provides HERG channel specificity of scorpion toxin BeKm-1.,Korolkova YV, Bocharov EV, Angelo K, Maslennikov IV, Grinenko OV, Lipkin AV, Nosyreva ED, Pluzhnikov KA, Olesen SP, Arseniev AS, Grishin EV J Biol Chem. 2002 Nov 8;277(45):43104-9. Epub 2002 Jul 31. PMID:12151390<ref>PMID:12151390</ref>
-[[1lgl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesobuthus_eupeus Mesobuthus eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LGL OCA].
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
 ==See Also==
 *[[Potassium channel toxin|Potassium channel toxin]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:012151390</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Mesobuthus eupeus]]
-[[Category: Angelo, K.]]
+[[Category: Angelo, K]]
-[[Category: Arseniev, A S.]]
+[[Category: Arseniev, A S]]
-[[Category: Bocharov, E V.]]
+[[Category: Bocharov, E V]]
-[[Category: Grinenko, O V.]]
+[[Category: Grinenko, O V]]
-[[Category: Grishin, E V.]]
+[[Category: Grishin, E V]]
-[[Category: Korolokova, Y V.]]
+[[Category: Korolokova, Y V]]
-[[Category: Lipkin, A V.]]
+[[Category: Lipkin, A V]]
-[[Category: Maslennikov, I V.]]
+[[Category: Maslennikov, I V]]
-[[Category: Nosireva, E D.]]
+[[Category: Nosireva, E D]]
-[[Category: Olesen, S P.]]
+[[Category: Olesen, S P]]
-[[Category: Pluzhnikov, K A.]]
+[[Category: Pluzhnikov, K A]]
 [[Category: Alpha-beta motif]]
 [[Category: Cysteine-knot motif]]
 [[Category: Toxin]]