4pby: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4pby]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PBY FirstGlance]. <br> | <table><tr><td colspan='2'>[[4pby]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PBY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PBY FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>< | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr> | ||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pby RCSB], [http://www.ebi.ac.uk/pdbsum/4pby PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pby FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pby OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pby RCSB], [http://www.ebi.ac.uk/pdbsum/4pby PDBsum]</span></td></tr> | ||
<table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Alqarni, S S.M | [[Category: Alqarni, S S.M]] | ||
[[Category: Laue, E D | [[Category: Laue, E D]] | ||
[[Category: Lejon, S | [[Category: Lejon, S]] | ||
[[Category: Mackay, J P | [[Category: Mackay, J P]] | ||
[[Category: Murthy, A | [[Category: Murthy, A]] | ||
[[Category: Silva, A P.G | [[Category: Silva, A P.G]] | ||
[[Category: Watson, A A | [[Category: Watson, A A]] | ||
[[Category: Cell cycle]] | [[Category: Cell cycle]] | ||
[[Category: Mta1]] | [[Category: Mta1]] | ||
Revision as of 13:06, 17 December 2014
Structure of the human RbAp48-MTA1(656-686) complexStructure of the human RbAp48-MTA1(656-686) complex
Structural highlights
Publication Abstract from PubMedThe Nucleosome Remodeling and Deacetylase (NuRD) complex is a widely conserved transcriptional co-regulator that harbors both nucleosome remodeling and histone deacetylase activities. It plays a critical role in the early stages of ES cell differentiation and the reprogramming of somatic to induced pluripotent stem cells. Abnormalities in several NuRD proteins are associated with cancer and ageing. We have investigated the architecture of NuRD by determining the structure of a sub-complex comprising RbAp48 and MTA1. Surprisingly, RbAp48 recognizes MTA1 using the same site that it uses to bind histone H4, showing that assembly into NuRD modulates RbAp46/48 interactions with histones. Taken together with other results, our data shows that the MTA proteins act as scaffolds for NuRD complex assembly. We further show that the RbAp48-MTA1 interaction is essential for the in vivo integration of RbAp46/48 into the NuRD complex. Insight into the architecture of the NuRD complex: Structure of the RbAp48-MTA1 sub-complex.,Alqarni SS, Murthy A, Zhang W, Przewloka MR, Silva AP, Watson AA, Lejon S, Pei XY, Smits AH, Kloet SL, Wang H, Shepherd NE, Stokes PH, Blobel GA, Vermeulen M, Glover DM, Mackay JP, Laue ED J Biol Chem. 2014 Jun 11. pii: jbc.M114.558940. PMID:24920672[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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