Ubiquitin conjugating enzyme: Difference between revisions

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Michal Harel, Alexander Berchansky, David A Taves

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 '''Ubiquitin conjugating enzyme''' (Ubc) or '''E2 enzyme''' catalyzes the second step in the ubiquitination of a protein tagged to be degraded by the proteasome.  Ubiquitin activating enzyme (E1) and ATP produce a C-terminal acyl adenylated ubiquitin molecule which binds to ubiquitin conjugating enzyme (Ubc) cysteine.  The Ubc then binds to ubiquitin ligase (E3) via a conserved binding region.  E3 catalyzes the transfer of ubiquitin from the Ubc-ubiquitin complex to a lysine residue of the target protein.  Ubc13 makes a catalytically active heterodimer with MMS2.
+</StructureSection>
 == 3D Structures of ubiquitin conjugating enzyme ==
 Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
-===Ubc===
+*Ubiquitin conjugating enzyme
-[[2aak]] – AtUbc – ''Arabidopsis thaliana''  <BR />
+**[[2aak]] – AtUbc – ''Arabidopsis thaliana''  <BR />
-[[2e2c]] – Ubc – ''Spisula solidissima''  <BR />
+**[[2e2c]] – Ubc – ''Spisula solidissima''  <BR />
-[[1q34]] – CeUbc – ''Caenorhabidis elegans''  <BR />
+**[[1q34]] – CeUbc – ''Caenorhabidis elegans''  <BR />
-[[2qcq]], [[1fzy]] – yUbc – yeast  <BR />
+**[[2qcq]], [[1fzy]] – yUbc – yeast  <BR />
-[[1jas]] – hUbc – human  <BR />
+**[[1jas]] – hUbc – human  <BR />
-[[2fo3]] – Ubc – ''Plasmodium vivax''  <BR />
+**[[2fo3]] – Ubc – ''Plasmodium vivax''  <BR />
-[[2h2y]] – PfUbc – ''Plasmodium falciparum''  <BR />
+**[[2h2y]] – PfUbc – ''Plasmodium falciparum''  <BR />
-[[1fxt]] – yUbc + ubiquitin  <BR />
+**[[1fxt]] – yUbc + ubiquitin  <BR />
-===Ubc1===
+*Ubiquitin conjugating enzyme 1
-[[1tte]] – yUbc  (mutant) <BR />
+**[[1tte]] – yUbc  (mutant) <BR />
-[[2aak]] – AtUbc <BR />
+**[[2aak]] – AtUbc <BR />
-[[1z3d]] – CeUbc   <BR />
+**[[1z3d]] – CeUbc   <BR />
-===Ubc2===
+*Ubiquitin conjugating enzyme 2
-[[1ayz]] – yUbc   <BR />
+**[[1ayz]] – yUbc   <BR />
-[[1z2u]] – CeUbc   <BR />
+**[[1z2u]] – CeUbc   <BR />
-===Ubc4===
+*Ubiquitin conjugating enzyme 4
-[[1qcq]] – yUbc   <BR />
+**[[1qcq]] – yUbc   <BR />
-[[4ii2]] – Ubc  (mutant) + E1 + ATP – fission yeast<BR />
+**[[4ii2]] – Ubc  (mutant) + E1 + ATP – fission yeast<BR />
-===Ubc5===
+*Ubiquitin conjugating enzyme 5
-[[2esk]], [[2c4o]], [[2clw]], [[3l1y]], [[3tgd]], [[2c4p]], [[1x23]] – hUbc  <BR />
+**[[2esk]], [[2c4o]], [[2clw]], [[3l1y]], [[3tgd]], [[2c4p]], [[1x23]] – hUbc  <BR />
-[[2eso]], [[2esp]], [[2esq]] – hUbc (mutant)<BR />
+**[[2eso]], [[2esp]], [[2esq]] – hUbc (mutant)<BR />
-[[1w4u]] – hUbc - NMR<BR />
+**[[1w4u]] – hUbc - NMR<BR />
-''Ubc5 complexes''
+*Ubiquitin conjugating enzyme 5 complexes
-[[1ur6]] – hUbc + Cnot4 - NMR<BR />
+**[[1ur6]] – hUbc + Cnot4 - NMR<BR />
-[[3eb6]] – Ubc + baculoviral IAP repeat-containing protein- frog<BR />
+**[[3eb6]] – Ubc + baculoviral IAP repeat-containing protein- frog<BR />
-[[4auq]] – hUbc (mutant) + baculoviral IAP repeat-containing protein + ubiquitin<BR />
+**[[4auq]] – hUbc (mutant) + baculoviral IAP repeat-containing protein + ubiquitin<BR />
-[[3ptf]], [[4ddg]], [[4ddi]] – hUbc + ubiquitin<BR />
+**[[3ptf]], [[4ddg]], [[4ddi]] – hUbc + ubiquitin<BR />
-[[2fuh]] – hUbc + ubiquitin - NMR<BR />
+**[[2fuh]] – hUbc + ubiquitin - NMR<BR />
-[[3a33]], [[3ugb]] – hUbc (mutant) + ubiquitin<BR />
+**[[3a33]], [[3ugb]] – hUbc (mutant) + ubiquitin<BR />
-[[3jvz]], [[3jw0]] – hUbc (mutant) + E3 NEDD4-2 + ubiquitin<BR />
+**[[3jvz]], [[3jw0]] – hUbc (mutant) + E3 NEDD4-2 + ubiquitin<BR />
-[[4ap4]] – hUbc + E3 Rnf4 + ubiquitin<BR />
+**[[4ap4]] – hUbc + E3 Rnf4 + ubiquitin<BR />
-[[3oj4]] – hUbc + tumor necrosis factor α-induced protein 3 + ubiquitin<BR />
+**[[3oj4]] – hUbc + tumor necrosis factor α-induced protein 3 + ubiquitin<BR />
-[[4a49]] – hUbc + E3 Cbl <BR />
+**[[4a49]] – hUbc + E3 Cbl <BR />
-[[4a4b]], [[4a4c]] – hUbc + E3 Cbl + ZAP-70 peptide<BR />
+**[[4a4b]], [[4a4c]] – hUbc + E3 Cbl + ZAP-70 peptide<BR />
-[[3l1z]] – hUbc + ubiquitin conjugating factor<BR />
+**[[3l1z]] – hUbc + ubiquitin conjugating factor<BR />
-[[3rpg]] – hUbc + E3 Ring2 + polycomb complex protein Bmi-1 <BR />
+**[[3rpg]] – hUbc + E3 Ring2 + polycomb complex protein Bmi-1 <BR />
-[[3zni]] – hUbc + ubiquitin + + E3 Cbl + ZAP-70 peptide <BR />
+**[[3zni]] – hUbc + ubiquitin + + E3 Cbl + ZAP-70 peptide <BR />
-===Ubc6===
+*Ubiquitin conjugating enzyme 6
-[[4jjq]] – hUbc + ubiquitin carboxyl terminal hydrolase <BR />
+**[[4jjq]] – hUbc + ubiquitin carboxyl terminal hydrolase <BR />
-===Ubc7===
+*Ubiquitin conjugating enzyme 7
-[[2ucz]] – yUbc   <BR />
+**[[2ucz]] – yUbc   <BR />
-[[2awf]], [[2cyx]] – hUbc   <BR />
+**[[2awf]], [[2cyx]] – hUbc   <BR />
-[[1c4z]] – hUbc + E3 HECT domain <BR />
+**[[1c4z]] – hUbc + E3 HECT domain <BR />
-[[1fbv]] – hUbc + E3 Cbl + ZAP-70 peptide<BR />
+**[[1fbv]] – hUbc + E3 Cbl + ZAP-70 peptide<BR />
-[[4jqu]] – hUbc + U7BR  <BR />
+**[[4jqu]] – hUbc + U7BR  <BR />
-[[3sqv]] – hUbc + secreted effector protein <BR />
+**[[3sqv]] – hUbc + secreted effector protein <BR />
-[[3sy2]] – hUbc + E3 Sopa <BR />
+**[[3sy2]] – hUbc + E3 Sopa <BR />
-===Ubc8===
+*Ubiquitin conjugating enzyme 8
-[[1y6l]], [[1wzw]], [[1wzv]] – hUbc   <BR />
+**[[1y6l]], [[1wzw]], [[1wzv]] – hUbc   <BR />
-[[2kjh]] – hUbc + ubiuqitin <BR />
+**[[2kjh]] – hUbc + ubiuqitin <BR />
-===Ubc9===
+*Ubiquitin conjugating enzyme 9 see [[SUMO conjugating enzyme Ubc9]]
-See [[SUMO conjugating enzyme Ubc9]]
+*Ubiquitin conjugating enzyme 10
-===Ubc10===
+**[[1i7k]] – hUbc (mutant)  <BR />
-[[1i7k]] – hUbc (mutant)  <BR />
+*Ubiquitin conjugating enzyme 12 (NEDD8 conjugating enzyme; Ubc F)
-===Ubc12 (NEDD8 conjugating enzyme; Ubc F)===
+**[[3o2u]] – yUbc <BR />
+**[[1tt5]] – hUbc + E1 Uba3, APPBP1 subunits  <BR />
+**[[1y8x]] – hUbc + E1 NEDD8 <BR />
+**[[2nvu]] – hUbc + E1 NEDD8 + NEDD8<BR />
+**[[3fn1]] – hUbc + E1 NEDD8-activating enzyme <BR />
+**[[3tdu]] – hUbc + cullin-1 + Dcn1-like protein <BR />
+**[[4gao]] – hUbc + Dcn1-like protein <BR />
+**[[3tdi]] – hUbc + defective in cullin neddylation protein <BR />
-[[3o2u]] – yUbc <BR />
+*Ubiquitin conjugating enzyme 13
-[[1tt5]] – hUbc + E1 Uba3, APPBP1 subunits  <BR />
-[[1y8x]] – hUbc + E1 NEDD8 <BR />
-[[2nvu]] – hUbc + E1 NEDD8 + NEDD8<BR />
-[[3fn1]] – hUbc + E1 NEDD8-activating enzyme <BR />
-[[3tdu]] – hUbc + cullin-1 + Dcn1-like protein <BR />
-[[4gao]] – hUbc + Dcn1-like protein <BR />
-[[3tdi]] – hUbc + defective in cullin neddylation protein <BR />
-===Ubc13===
+**[[1jbb]] – yUbc  <BR />
+**[[1jat]] – yUbc/Mms2  <BR />
+**[[1j74]] – hMms2  <BR />
+**[[1j7d]] – hUbc/Mms2  <BR />
+**[[4fh1]] – hUbc (mutant) <BR />
-[[1jbb]] – yUbc  <BR />
+*Ubiquitin conjugating enzyme 13 complexes
-[[1jat]] – yUbc/Mms2  <BR />
-[[1j74]] – hMms2  <BR />
-[[1j7d]] – hUbc/Mms2  <BR />
-[[4fh1]] – hUbc (mutant) <BR />
-''Ubc13 complexes''
+**[[2c2v]] – hUbc + CHIP + Uev1a  <BR />
+**[[3hct]], [[3hcu]] – hUbc + TNF receptor associated factor 6  <BR />
+**[[4dhi]] – CeUbc + OTUB1  <BR />
+**[[4dhi]], [[4dhz]] – hUbc + OTUB1 + ubiquitin + ubiquitin aldehyde <BR />
+**[[4epo]], [[4orh]] – hUbc/Mms2 + E3 Rnf8 <BR />
+**[[3von]] – hUbc/Mms2 + OTUB1 <BR />
+**[[1zgu]] – hMms2 + ubiquitin - NMR <BR />
+**[[2gmi]] – hUbc/Mms2 (mutant) + ubiquitin <BR />
+**[[4ip3]], [[3w31]] – hUbc + Orf169b <BR />
+**[[2oxq]] – Ubc + CHIP U-box - zebrafish<BR />
-[[2c2v]] – hUbc + CHIP + Uev1a  <BR />
+*Ubiquitin conjugating enzyme B
-[[3hct]], [[3hcu]] – hUbc + TNF receptor associated factor 6  <BR />
-[[4dhi]] – CeUbc + OTUB1  <BR />
-[[4dhi]], [[4dhz]] – hUbc + OTUB1 + ubiquitin + ubiquitin aldehyde <BR />
-[[4epo]], [[4orh]] – hUbc/Mms2 + E3 Rnf8 <BR />
-[[3von]] – hUbc/Mms2 + OTUB1 <BR />
-[[1zgu]] – hMms2 + ubiquitin - NMR <BR />
-[[2gmi]] – hUbc/Mms2 (mutant) + ubiquitin <BR />
-[[4ip3]], [[3w31]] – hUbc + Orf169b <BR />
-[[2oxq]] – Ubc + CHIP U-box - zebrafish<BR />
-===Ubc B===
+**[[2yb6]] – hUbc<br />
+**[[2y4w]] – hUbc - NMR <BR />
+**[[2ybf]] – hUbc + Rad18<br />
-[[2yb6]] – hUbc<br />
+*Ubiquitin conjugating enzyme D
-[[2y4w]] – hUbc - NMR <BR />
-[[2ybf]] – hUbc + Rad18<br />
-===Ubc D===
+**[[2yho]] – hUbc D1 + E3 Mylip <BR />
+**[[4ldt]] – hUbc D2 + OTUB1 + ubiquitin <BR />
+**[[4bvu]] – hUbc D3 + OspG + ubiquitin <BR />
-[[2yho]] – hUbc D1 + E3 Mylip <BR />
+*Ubiquitin conjugating enzyme E1
-[[4ldt]] – hUbc D2 + OTUB1 + ubiquitin <BR />
-[[4bvu]] – hUbc D3 + OspG + ubiquitin <BR />
-===Ubc E1===
+**[[3bzh]] – hUbc  <BR />
-[[3bzh]] – hUbc  <BR />
+*Ubiquitin conjugating enzyme G2
-===Ubc G2===
+**[[3fsh]] – hUbc + autocrine motility factor receptor <BR />
+**[[2kly]] – hUbc - NMR<BR />
+**[[2lxp]] – hUbc + AMFR peptide - NMR<BR />
+**[[3h8k]], [[4lad]] – hUbc + AMFR peptide <BR />
-[[3fsh]] – hUbc + autocrine motility factor receptor <BR />
+*Ubiquitin conjugating enzyme H
-[[2kly]] – hUbc - NMR<BR />
-[[2lxp]] – hUbc + AMFR peptide - NMR<BR />
-[[3h8k]], [[4lad]] – hUbc + AMFR peptide <BR />
-===Ubc H===
+**[[2z5d]] – hUbc  <BR />
-[[2z5d]] – hUbc  <BR />
+*Ubiquitin conjugating enzyme J2
-===Ubc J2===
+**[[2f4w]] – hUbc  <BR />
-[[2f4w]] – hUbc  <BR />
+*Ubiquitin conjugating enzyme N
-===Ubc N===
+**[[4dhj]] – hUbc  + ubiquitin + OTUB1<BR />
-[[4dhj]] – hUbc  + ubiquitin + OTUB1<BR />
+*Ubiquitin conjugating enzyme Q
-===Ubc Q===
+**[[2qgx]] – hUbc  <BR />
-[[2qgx]] – hUbc  <BR />
+*Ubiquitin conjugating enzyme R1
-===Ubc R1===
+**[[3rz3]] – hUbc + inhibitor <BR />
+**[[4mdk]] – hUbc + ubiquitin + inhibitor <BR />
-[[3rz3]] – hUbc + inhibitor <BR />
+*Ubiquitin conjugating enzyme S
-[[4mdk]] – hUbc + ubiquitin + inhibitor <BR />
-===Ubc S===
 [[1zdn]] – hUbc  <BR />