Tumor necrosis factor: Difference between revisions

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'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis.  TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome).  It is involved in the regulation of the immune cells.  TNF is a transmembrane homotrimer.  The soluble TNF is produced by cleavage by the metalloprotease TNF alpha converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]).   
'''Tumor necrosis factor''' (TNF) is a cytokine which can cause apoptosis.  TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome).  It is involved in the regulation of the immune cells.  TNF is a transmembrane homotrimer.  The soluble TNF is produced by cleavage by the metalloprotease TNF alpha converting enzyme (TACE or ADAM17 see [[A Disintegrin And Metalloproteinase]]).   
</StructureSection>


== 3D Structures of tumor necrosis factor ==
== 3D Structures of tumor necrosis factor ==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


===TNF alpha===
*TNF alpha


[[1tnf]] – hTNF – human  <BR />
**[[1tnf]] – hTNF – human  <BR />
[[2tun]], [[1a8m]], [[4tsv]], [[5tsw]], [[2e7e]], [[2zjc]], [[2zpx]] – hTNF (mutant)  <BR />
**[[2tun]], [[1a8m]], [[4tsv]], [[5tsw]], [[2e7e]], [[2zjc]], [[2zpx]] – hTNF (mutant)  <BR />
[[2tnf]] – TNF – mouse  <BR />
**[[2tnf]] – TNF – mouse  <BR />
[[2az5]] – hTNF + inhibitor  <BR />
**[[2az5]] – hTNF + inhibitor  <BR />
[[3it8]] – hTNF + poxvirus 2L protein  <BR />
**[[3it8]] – hTNF + poxvirus 2L protein  <BR />
[[3l9j]] – hTNF + antagonist  <BR />
**[[3l9j]] – hTNF + antagonist  <BR />
[[3alq]] – hTNF (mutant) + TNF receptor  <BR />
**[[3alq]] – hTNF (mutant) + TNF receptor  <BR />
[[4g3y]], [[3wd5]] – hTNF + antibody  <BR />
**[[4g3y]], [[3wd5]] – hTNF + antibody  <BR />


===TNF beta===
*TNF beta


[[1tnr]] – hTNF + TNF receptor p55  <BR />
**[[1tnr]] – hTNF + TNF receptor p55  <BR />


===TNF ===
*TNF  
 
[[2vfj]] – hTNF ovarian tumor domain  <BR />


**[[2vfj]] – hTNF ovarian tumor domain  <BR />
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:17, 16 December 2014


Tumor necrosis factor (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNF alpha converting enzyme (TACE or ADAM17 see A Disintegrin And Metalloproteinase).

Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry 2az5)

Drag the structure with the mouse to rotate

3D Structures of tumor necrosis factor3D Structures of tumor necrosis factor

Updated on 16-December-2014

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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