1oog: Difference between revisions
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'''Complex of Drosophila odorant binding protein LUSH with propanol''' | {{Structure | ||
|PDB= 1oog |SIZE=350|CAPTION= <scene name='initialview01'>1oog</scene>, resolution 1.45Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene> and <scene name='pdbligand=POL:N-PROPANOL'>POL</scene> | |||
|ACTIVITY= | |||
|GENE= lush ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster]) | |||
}} | |||
'''Complex of Drosophila odorant binding protein LUSH with propanol''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1OOG is a [ | 1OOG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OOG OCA]. | ||
==Reference== | ==Reference== | ||
Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster., Kruse SW, Zhao R, Smith DP, Jones DN, Nat Struct Biol. 2003 Sep;10(9):694-700. Epub 2003 Jul 27. PMID:[http:// | Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster., Kruse SW, Zhao R, Smith DP, Jones DN, Nat Struct Biol. 2003 Sep;10(9):694-700. Epub 2003 Jul 27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12881720 12881720] | ||
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: odorant binding]] | [[Category: odorant binding]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:13:36 2008'' | ||
Revision as of 14:13, 20 March 2008
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| , resolution 1.45Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Gene: | lush (Drosophila melanogaster) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Complex of Drosophila odorant binding protein LUSH with propanol
OverviewOverview
We have solved the high-resolution crystal structures of the Drosophila melanogaster alcohol-binding protein LUSH in complex with a series of short-chain n-alcohols. LUSH is the first known nonenzyme protein with a defined in vivo alcohol-binding function. The structure of LUSH reveals a set of molecular interactions that define a specific alcohol-binding site. A group of amino acids, Thr57, Ser52 and Thr48, form a network of concerted hydrogen bonds between the protein and the alcohol that provides a structural motif to increase alcohol-binding affinity at this site. This motif seems to be conserved in a number of mammalian ligand-gated ion channels that are directly implicated in the pharmacological effects of alcohol. Further, these sequences are found in regions of ion channels that are known to confer alcohol sensitivity. We suggest that the alcohol-binding site in LUSH represents a general model for alcohol-binding sites in proteins.
About this StructureAbout this Structure
1OOG is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
ReferenceReference
Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster., Kruse SW, Zhao R, Smith DP, Jones DN, Nat Struct Biol. 2003 Sep;10(9):694-700. Epub 2003 Jul 27. PMID:12881720
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