1oo5: Difference between revisions

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[[Image:1oo5.jpg|left|200px]]<br /><applet load="1oo5" size="350" color="white" frame="true" align="right" spinBox="true"
[[Image:1oo5.jpg|left|200px]]
caption="1oo5, resolution 2.50&Aring;" />
 
'''Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of the Enzyme Active Form and Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs'''<br />
{{Structure
|PDB= 1oo5 |SIZE=350|CAPTION= <scene name='initialview01'>1oo5</scene>, resolution 2.50&Aring;
|SITE=
|LIGAND= <scene name='pdbligand=FMN:FLAVIN MONONUCLEOTIDE'>FMN</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/6,7-dihydropteridine_reductase 6,7-dihydropteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.34 1.5.1.34]
|GENE=
}}
 
'''Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of the Enzyme Active Form and Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs'''
 


==Overview==
==Overview==
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==About this Structure==
==About this Structure==
1OO5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=FMN:'>FMN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/6,7-dihydropteridine_reductase 6,7-dihydropteridine reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.34 1.5.1.34] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OO5 OCA].  
1OO5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OO5 OCA].  


==Reference==
==Reference==
Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form., Johansson E, Parkinson GN, Denny WA, Neidle S, J Med Chem. 2003 Sep 11;46(19):4009-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12954054 12954054]
Studies on the nitroreductase prodrug-activating system. Crystal structures of complexes with the inhibitor dicoumarol and dinitrobenzamide prodrugs and of the enzyme active form., Johansson E, Parkinson GN, Denny WA, Neidle S, J Med Chem. 2003 Sep 11;46(19):4009-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12954054 12954054]
[[Category: 6,7-dihydropteridine reductase]]
[[Category: 6,7-dihydropteridine reductase]]
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: nitroreductase]]
[[Category: nitroreductase]]


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