4e13: Difference between revisions
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[[ | ==Substrate-directed dual catalysis of dicarbonyl compounds by diketoreductase== | ||
<StructureSection load='4e13' size='340' side='right' caption='[[4e13]], [[Resolution|resolution]] 2.08Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4e13]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acinetobacter_baylyi Acinetobacter baylyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4E13 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dyd|4dyd]], [[4e12|4e12]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4e13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e13 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4e13 RCSB], [http://www.ebi.ac.uk/pdbsum/4e13 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Diketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product. | |||
Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase.,Lu M, Huang Y, White MA, Wu X, Liu N, Cheng X, Chen Y Chem Commun (Camb). 2012 Oct 24;48(92):11352-4. doi: 10.1039/c2cc36334h. PMID:23073461<ref>PMID:23073461</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
== | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Acinetobacter baylyi]] | [[Category: Acinetobacter baylyi]] | ||
[[Category: Chen, Y | [[Category: Chen, Y]] | ||
[[Category: Cheng, X | [[Category: Cheng, X]] | ||
[[Category: Huang, Y | [[Category: Huang, Y]] | ||
[[Category: Liu, N | [[Category: Liu, N]] | ||
[[Category: Lu, M | [[Category: Lu, M]] | ||
[[Category: White, M A | [[Category: White, M A]] | ||
[[Category: Wu, X | [[Category: Wu, X]] | ||
[[Category: Nadh]] | [[Category: Nadh]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||