4a11: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:4a11.jpg|left|200px]]
+==STRUCTURE OF THE HSDDB1-HSCSA COMPLEX==
+<StructureSection load='4a11' size='340' side='right' caption='[[4a11]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4a11]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A11 FirstGlance]. <br>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2b5l|2b5l]], [[2b5m|2b5m]], [[2hye|2hye]], [[2b5n|2b5n]], [[4a0l|4a0l]], [[4a0a|4a0a]], [[4a0b|4a0b]], [[4a08|4a08]], [[4a09|4a09]], [[4a0k|4a0k]], [[3ei1|3ei1]], [[3ei2|3ei2]], [[3ei3|3ei3]], [[3ei4|3ei4]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a11 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a11 RCSB], [http://www.ebi.ac.uk/pdbsum/4a11 PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The DDB1-CUL4-RBX1 (CRL4) ubiquitin ligase family regulates a diverse set of cellular pathways through dedicated substrate receptors (DCAFs). The DCAF DDB2 detects UV-induced pyrimidine dimers in the genome and facilitates nucleotide excision repair. We provide the molecular basis for DDB2 receptor-mediated cyclobutane pyrimidine dimer recognition in chromatin. The structures of the fully assembled DDB1-DDB2-CUL4A/B-RBX1 (CRL4(DDB2)) ligases reveal that the mobility of the ligase arm creates a defined ubiquitination zone around the damage, which precludes direct ligase activation by DNA lesions. Instead, the COP9 signalosome (CSN) mediates the CRL4(DDB2) inhibition in a CSN5 independent, nonenzymatic, fashion. In turn, CSN inhibition is relieved upon DNA damage binding to the DDB2 module within CSN-CRL4(DDB2). The Cockayne syndrome A DCAF complex crystal structure shows that CRL4(DCAF(WD40)) ligases share common architectural features. Our data support a general mechanism of ligase activation, which is induced by CSN displacement from CRL4(DCAF) on substrate binding to the DCAF.
-<!--
+The Molecular Basis of CRL4(DDB2/CSA) Ubiquitin Ligase Architecture, Targeting, and Activation.,Fischer ES, Scrima A, Bohm K, Matsumoto S, Lingaraju GM, Faty M, Yasuda T, Cavadini S, Wakasugi M, Hanaoka F, Iwai S, Gut H, Sugasawa K, Thoma NH Cell. 2011 Nov 23;147(5):1024-39. PMID:22118460<ref>PMID:22118460</ref>
-The line below this paragraph, containing "STRUCTURE_4a11", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
-{{STRUCTURE_4a11|  PDB=4a11  |  SCENE=  }}
-===STRUCTURE OF THE HSDDB1-HSCSA COMPLEX===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+==See Also==
-<!--
+*[[DNA damage-binding protein|DNA damage-binding protein]]
-The line below this paragraph, {{ABSTRACT_PUBMED_22118460}}, adds the Publication Abstract to the page
+== References ==
-(as it appears on PubMed at http://www.pubmed.gov), where 22118460 is the PubMed ID number.
+<references/>
--->
+__TOC__
-{{ABSTRACT_PUBMED_22118460}}
+</StructureSection>
-==About this Structure==
-[[4a11]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A11 OCA].
-==Reference==
-<ref group="xtra">PMID:022118460</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Bohm, K.]]
+[[Category: Bohm, K]]
-[[Category: Fischer, E S.]]
+[[Category: Fischer, E S]]
-[[Category: Gut, H.]]
+[[Category: Gut, H]]
-[[Category: Scrima, A.]]
+[[Category: Scrima, A]]
-[[Category: Thomae, N H.]]
+[[Category: Thomae, N H]]
 [[Category: Dna binding protein]]
 [[Category: Dna damage repair]]