1nz8: Difference between revisions

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NusG (Thermus thermophilus)

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Solution Structure of the N-utilisation substance G (NusG) N-terminal (NGN) domain from Thermus thermophilus

OverviewOverview

NusG is an essential bacterial protein modulator of transcriptional elongation and termination events, and interacts directly with RNA polymerase and Rho protein. Found also in Archaea, NusG shows stretches of sequence similarity to the eukaryotic transcription elongation factor Spt5. Herein, the three-dimensional solution structure of the bacterial NusG from Thermus thermophilus, which shows 43% amino acid sequence similarity to the Escherichia coli NusG, is described, and a survey of NusG and Spt5 amino acid sequences is presented. Although there is a clear evolutionary and functional relationship between these proteins, it is evident from the structural, sequence, and biochemical data that their binding specificities to both nucleic acids and other proteins differ.

About this StructureAbout this Structure

1NZ8 is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

ReferenceReference

Structural and sequence comparisons arising from the solution structure of the transcription elongation factor NusG from Thermus thermophilus., Reay P, Yamasaki K, Terada T, Kuramitsu S, Shirouzu M, Yokoyama S, Proteins. 2004 Jul 1;56(1):40-51. PMID:15162485

Page seeded by OCA on Thu Mar 20 13:03:38 2008

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OCA

@@ Line 1: / Line 1: @@
-[[Image:1nz8.jpg|left|200px]]<br /><applet load="1nz8" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1nz8.jpg|left|200px]]
-caption="1nz8" />
-'''Solution Structure of the N-utilisation substance G (NusG) N-terminal (NGN) domain from Thermus thermophilus'''<br />
+ {{Structure
+|PDB= 1nz8 |SIZE=350|CAPTION= <scene name='initialview01'>1nz8</scene>
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE= NusG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])
+}}
+'''Solution Structure of the N-utilisation substance G (NusG) N-terminal (NGN) domain from Thermus thermophilus'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-NZ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZ8 OCA].
+NZ8 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZ8 OCA].
 ==Reference==
-Structural and sequence comparisons arising from the solution structure of the transcription elongation factor NusG from Thermus thermophilus., Reay P, Yamasaki K, Terada T, Kuramitsu S, Shirouzu M, Yokoyama S, Proteins. 2004 Jul 1;56(1):40-51. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15162485 15162485]
+Structural and sequence comparisons arising from the solution structure of the transcription elongation factor NusG from Thermus thermophilus., Reay P, Yamasaki K, Terada T, Kuramitsu S, Shirouzu M, Yokoyama S, Proteins. 2004 Jul 1;56(1):40-51. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15162485 15162485]
 [[Category: Single protein]]
 [[Category: Thermus thermophilus]]
@@ Line 23: / Line 32: @@
 [[Category: riken structural genomics/proteomics initiative]]
 [[Category: rsgi]]
-[[Category: structural genomics]]
+[[Category: structural genomic]]
 [[Category: termination]]
 [[Category: transcription elongation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:11:46 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:03:38 2008''