1nz0: Difference between revisions

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Revision as of 14:03, 20 March 2008

File:1nz0.gif

, resolution 1.20Å

Ligands:

Gene:

RNPA OR TM1463 (Thermotoga maritima)

Activity:

Ribonuclease P, with EC number 3.1.26.5

Coordinates:

save as pdb, mmCIF, xml

RNASE P PROTEIN FROM THERMOTOGA MARITIMA

OverviewOverview

The structure of RNase P protein from the hyperthermophilic bacterium Thermotoga maritima was determined at 1.2-A resolution by using x-ray crystallography. This protein structure is from an ancestral-type RNase P and bears remarkable similarity to the recently determined structures of RNase P proteins from bacteria that have the distinct, Bacillus type of RNase P. These two types of protein span the extent of bacterial RNase P diversity, so the results generalize the structure of the bacterial RNase P protein. The broad phylogenetic conservation of structure and distribution of potential RNA-binding elements in the RNase P proteins indicate that all of these homologous proteins bind to their cognate RNAs primarily by interaction with the phylogenetically conserved core of the RNA. The protein is found to dimerize through an extensive, well-ordered interface. This dimerization may reflect a mechanism of thermal stability of the protein before assembly with the RNA moiety of the holoenzyme.

About this StructureAbout this Structure

1NZ0 is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

ReferenceReference

High-resolution structure of RNase P protein from Thermotoga maritima., Kazantsev AV, Krivenko AA, Harrington DJ, Carter RJ, Holbrook SR, Adams PD, Pace NR, Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7497-502. Epub 2003 Jun 10. PMID:12799461

Page seeded by OCA on Thu Mar 20 13:03:32 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1nz0.gif|left|200px]]<br /><applet load="1nz0" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1nz0.gif|left|200px]]
-caption="1nz0, resolution 1.20&Aring;" />
-'''RNASE P PROTEIN FROM THERMOTOGA MARITIMA'''<br />
+ {{Structure
+|PDB= 1nz0 |SIZE=350|CAPTION= <scene name='initialview01'>1nz0</scene>, resolution 1.20&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
+|ACTIVITY= [http://en.wikipedia.org/wiki/Ribonuclease_P Ribonuclease P], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.5 3.1.26.5]
+|GENE= RNPA OR TM1463 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2336 Thermotoga maritima])
+}}
+'''RNASE P PROTEIN FROM THERMOTOGA MARITIMA'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-NZ0 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Ribonuclease_P Ribonuclease P], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.26.5 3.1.26.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZ0 OCA].
+NZ0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZ0 OCA].
 ==Reference==
-High-resolution structure of RNase P protein from Thermotoga maritima., Kazantsev AV, Krivenko AA, Harrington DJ, Carter RJ, Holbrook SR, Adams PD, Pace NR, Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7497-502. Epub 2003 Jun 10. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12799461 12799461]
+High-resolution structure of RNase P protein from Thermotoga maritima., Kazantsev AV, Krivenko AA, Harrington DJ, Carter RJ, Holbrook SR, Adams PD, Pace NR, Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7497-502. Epub 2003 Jun 10. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12799461 12799461]
 [[Category: Ribonuclease P]]
 [[Category: Single protein]]
@@ Line 31: / Line 40: @@
 [[Category: psi]]
 [[Category: rnase]]
-[[Category: structural genomics]]
+[[Category: structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:11:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 13:03:32 2008''