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[[ | ==Crystal Structure of HIV-1 Protease Mutant I47V with novel P1'-Ligands GRL-02031== | ||
<StructureSection load='3vf5' size='340' side='right' caption='[[3vf5]], [[Resolution|resolution]] 1.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3vf5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(bru_isolate) Human immunodeficiency virus type 1 (bru isolate)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VF5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3VF5 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=031:(3AS,5R,6AR)-HEXAHYDRO-2H-CYCLOPENTA[B]FURAN-5-YL+[(1S,2R)-1-BENZYL-2-HYDROXY-3-([(4-METHOXYPHENYL)SULFONYL]{[(2R)-5-OXOPYRROLIDIN-2-YL]METHYL}AMINO)PROPYL]CARBAMATE'>031</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3h5b|3h5b]], [[3vf7|3vf7]], [[3vfa|3vfa]], [[3vfb|3vfb]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gag-pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11686 Human immunodeficiency virus type 1 (BRU ISOLATE)])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3vf5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3vf5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3vf5 RCSB], [http://www.ebi.ac.uk/pdbsum/3vf5 PDBsum]</span></td></tr> | |||
</table> | |||
==See Also== | |||
*[[Virus protease|Virus protease]] | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
[[ | |||
[[Category: HIV-1 retropepsin]] | [[Category: HIV-1 retropepsin]] | ||
[[Category: Chang, Y C.E | [[Category: Chang, Y C.E]] | ||
[[Category: Wang, Y F | [[Category: Wang, Y F]] | ||
[[Category: Weber, I T | [[Category: Weber, I T]] | ||
[[Category: Yu, X X | [[Category: Yu, X X]] | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: P1'-ligand]] | [[Category: P1'-ligand]] | ||
[[Category: Protease inhibitor]] | [[Category: Protease inhibitor]] | ||
Revision as of 18:28, 9 December 2014
Crystal Structure of HIV-1 Protease Mutant I47V with novel P1'-Ligands GRL-02031Crystal Structure of HIV-1 Protease Mutant I47V with novel P1'-Ligands GRL-02031
Structural highlights
See Also |
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