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[[ | ==Crystal structure of crosslinked GltPh V216C-M385C mutant== | ||
<StructureSection load='3v8f' size='340' side='right' caption='[[3v8f]], [[Resolution|resolution]] 3.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3v8f]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii_ot3 Pyrococcus horikoshii ot3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3V8F FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ASP:ASPARTIC+ACID'>ASP</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2nwl|2nwl]], [[2nww|2nww]], [[2nwx|2nwx]], [[1xfh|1xfh]], [[3kbc|3kbc]], [[3v8g|3v8g]]</td></tr> | |||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PH1295 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=70601 Pyrococcus horikoshii OT3])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v8f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v8f RCSB], [http://www.ebi.ac.uk/pdbsum/3v8f PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
We report a structure of a trimeric glutamate transporter homolog from Pyrococcus horikoshii with two protomers in an inward facing state and the third in an intermediate conformation between the outward and inward facing states. The intermediate shows a cavity in the thinnest region of the transporter, which is potentially accessible to extracellular and cytoplasmic solutions. Our findings suggest a structural principle by which transport intermediates may mediate uncoupled permeation of polar solutes. | |||
Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog.,Verdon G, Boudker O Nat Struct Mol Biol. 2012 Feb 12;19(3):355-7. doi: 10.1038/nsmb.2233. PMID:22343718<ref>PMID:22343718</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
== | __TOC__ | ||
</StructureSection> | |||
[[Category: Pyrococcus horikoshii ot3]] | [[Category: Pyrococcus horikoshii ot3]] | ||
[[Category: Boudker, O | [[Category: Boudker, O]] | ||
[[Category: Verdon, G | [[Category: Verdon, G]] | ||
[[Category: L-arpartate]] | [[Category: L-arpartate]] | ||
[[Category: Membrane]] | [[Category: Membrane]] | ||
[[Category: Sodium ion]] | [[Category: Sodium ion]] | ||
[[Category: Transport protein]] | [[Category: Transport protein]] | ||
Revision as of 17:56, 9 December 2014
Crystal structure of crosslinked GltPh V216C-M385C mutantCrystal structure of crosslinked GltPh V216C-M385C mutant
Structural highlights
Publication Abstract from PubMedWe report a structure of a trimeric glutamate transporter homolog from Pyrococcus horikoshii with two protomers in an inward facing state and the third in an intermediate conformation between the outward and inward facing states. The intermediate shows a cavity in the thinnest region of the transporter, which is potentially accessible to extracellular and cytoplasmic solutions. Our findings suggest a structural principle by which transport intermediates may mediate uncoupled permeation of polar solutes. Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog.,Verdon G, Boudker O Nat Struct Mol Biol. 2012 Feb 12;19(3):355-7. doi: 10.1038/nsmb.2233. PMID:22343718[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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