3sgv: Difference between revisions

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-[[Image:3sgv.png|left|200px]]
+==Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1290==
+<StructureSection load='3sgv' size='340' side='right' caption='[[3sgv]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3sgv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SGV FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2BJ:2-{[3-(3,4-DIMETHYLPHENOXY)PHENYL]CARBAMOYL}-4-NITROBENZOIC+ACID'>2BJ</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sgx|3sgx]], [[3sh0|3sh0]], [[3sgt|3sgt]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b0174, ispU, JW0169, rth, uppS, yaeS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Di-trans,poly-cis-decaprenylcistransferase Di-trans,poly-cis-decaprenylcistransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.31 2.5.1.31] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sgv RCSB], [http://www.ebi.ac.uk/pdbsum/3sgv PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+With the rise in resistance to antibiotics such as methicillin, there is a need for new drugs. We report here the discovery and X-ray crystallographic structures of 10 chemically diverse compounds (benzoic, diketo, and phosphonic acids, as well as a bisamidine and a bisamine) that inhibit bacterial undecaprenyl diphosphate synthase, an essential enzyme involved in cell wall biosynthesis. The inhibitors bind to one or more of the four undecaprenyl diphosphate synthase inhibitor binding sites identified previously, with the most active leads binding to site 4, outside the catalytic center. The most potent leads are active against Staphylococcus aureus [minimal inhibitory concentration (MIC)(90) approximately 0.25 microg/mL], and one potently synergizes with methicillin (fractional inhibitory concentration index = 0.25) and is protective in a mouse infection model. These results provide numerous leads for antibacterial development and open up the possibility of restoring sensitivity to drugs such as methicillin, using combination therapies.
-{{STRUCTURE_3sgv|  PDB=3sgv  |  SCENE=  }}
+Antibacterial drug leads targeting isoprenoid biosynthesis.,Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, Nizet V, McCammon JA, Oldfield E Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):123-8. doi: 10.1073/pnas.1219899110. , Epub 2012 Dec 17. PMID:23248302<ref>PMID:23248302</ref>
-===Crystal Structure of E. coli undecaprenyl pyrophosphate synthase in complex with BPH-1290===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_23248302}}
+==See Also==
+*[[Undecaprenyl pyrophosphate synthase|Undecaprenyl pyrophosphate synthase]]
-==About this Structure==
+== References ==
-[[3sgv]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGV OCA].
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Di-trans,poly-cis-decaprenylcistransferase]]
 [[Category: Escherichia coli k-12]]
-[[Category: Cao, R.]]
+[[Category: Cao, R]]
-[[Category: Liu, Y L.]]
+[[Category: Liu, Y L]]
-[[Category: Oldfield, E.]]
+[[Category: Oldfield, E]]
 [[Category: Alpha/beta]]
 [[Category: Transferase]]