3sxs: Difference between revisions

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-[[Image:3sxs.png|left|200px]]
+==Crystal structure of BMX non-receptor tyrosine kinase complexed with PP2==
+<StructureSection load='3sxs' size='340' side='right' caption='[[3sxs]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3sxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SXS FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PP2:1-TERT-BUTYL-3-(4-CHLORO-PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE'>PP2</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sxr|3sxr]]</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AGMX1, ATK, BMX, BPK, BTK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sxs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sxs OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sxs RCSB], [http://www.ebi.ac.uk/pdbsum/3sxs PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Bone marrow kinase in the X chromosome (BMX), a member of the Tec family of tyrosine kinases, plays a role in both monocyte/macrophage trafficking as well as cytokine secretion. Although the structures of Tec family kinases Bruton's tyrosine kinase (BTK) and IL-2-inducible T cell kinase (ITK) are known, the crystal structures of other Tec family kinases have remained elusive. We report the X-ray crystal structures of BMX in complex with dasatinib at 2.4A resolution and PP2 at 1.9A resolution. The BMX structures reveal a typical kinase protein fold; with well ordered protein conformation that includes an open/extended activation loop and a stabilized DFG-motif rendering the kinase in an inactive conformation. Dasatinib and PP2 bind to BMX in the ATP binding pocket and display similar binding modes to that observed in other Tec and Src protein kinases. The BMX structures identify conformational elements of the DFG-motif that could potentially be utilized to design potent and/or selective BMX inhibitors.
-{{STRUCTURE_3sxs|  PDB=3sxs  |  SCENE=  }}
+X-Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome; a Tec Family Kinase.,Muckelbauer J, Sack JS, Ahmed N, Burke J, Chang CY, Gao M, Tino J, Xie D, Tebben AJ Chem Biol Drug Des. 2011 Aug 30. doi: 10.1111/j.1747-0285.2011.01230.x. PMID:21883956<ref>PMID:21883956</ref>
-===Crystal structure of BMX non-receptor tyrosine kinase complexed with PP2===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_21883956}}
-==About this Structure==
-[[3sxs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SXS OCA].
 ==See Also==
 *[[Tyrosine kinase|Tyrosine kinase]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:021883956</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
 [[Category: Non-specific protein-tyrosine kinase]]
-[[Category: Muckelbauer, J.]]
+[[Category: Muckelbauer, J]]
-[[Category: Sack, J.]]
+[[Category: Sack, J]]
 [[Category: Transferase-transferase inhibitor complex]]