3s2p: Difference between revisions

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-[[Image:3s2p.png|left|200px]]
+==Crystal structure of CDK2 with a 2-aminopyrimidine compound==
+<StructureSection load='3s2p' size='340' side='right' caption='[[3s2p]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3s2p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S2P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3S2P FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PMU:(3S,4S)-1-{3-[2-AMINO-6-(PROPAN-2-YL)PYRIMIDIN-4-YL]-4-HYDROXYPHENYL}PYRROLIDINE-3,4-DIOL'>PMU</scene></td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=500 Thermomicrobium roseum])</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cyclin-dependent_kinase Cyclin-dependent kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.22 2.7.11.22] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3s2p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s2p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3s2p RCSB], [http://www.ebi.ac.uk/pdbsum/3s2p PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+A series of new 2-(2-aminopyrimidin-4-yl)phenol derivatives were synthesized as potential antitumor compounds. Substitution with pyrrolidine-3,4-diol at the 4-position of phenol provided potent inhibitory activity against CDK1 and CDK2. X-ray crystal structural studies were performed to account for the effect of the substituent on both the enzymatic and cell growth inhibitory activities.
-{{STRUCTURE_3s2p|  PDB=3s2p  |  SCENE=  }}
+Discovery of a novel class of 2-aminopyrimidines as CDK1 and CDK2 inhibitors.,Lee J, Kim KH, Jeong S Bioorg Med Chem Lett. 2011 Jul 15;21(14):4203-5. Epub 2011 May 27. PMID:21684737<ref>PMID:21684737</ref>
-===Crystal structure of CDK2 with a 2-aminopyrimidine compound===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_21684737}}
-==About this Structure==
-[[3s2p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S2P OCA].
 ==See Also==
-*[[Cell Division Protein Kinase 2|Cell Division Protein Kinase 2]]
+*[[Cell division protein kinase 2|Cell division protein kinase 2]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:021684737</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Cyclin-dependent kinase]]
 [[Category: Thermomicrobium roseum]]
-[[Category: Jeong, S.]]
+[[Category: Jeong, S]]
-[[Category: Kim, K H.]]
+[[Category: Kim, K H]]
-[[Category: Lee, J.]]
+[[Category: Lee, J]]
 [[Category: Cell division protein kinase 2]]
 [[Category: Protein kinase]]
 [[Category: Transferase]]
 [[Category: Transferase-transferase inhibitor complex]]