3q6f: Difference between revisions

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-[[Image:3q6f.png|left|200px]]
+==Crystal structure of Fab of human mAb 2909 specific for quaternary neutralizing epitope of HIV-1 gp120==
+<StructureSection load='3q6f' size='340' side='right' caption='[[3q6f]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3q6f]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q6F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q6F FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TYS:O-SULFO-L-TYROSINE'>TYS</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3q6g|3q6g]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q6f OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q6f RCSB], [http://www.ebi.ac.uk/pdbsum/3q6f PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The quaternary neutralizing epitope (QNE) of HIV-1 gp120 is preferentially expressed on the trimeric envelope spikes of intact HIV virions, and QNE-specific monoclonal antibodies (mAbs) potently neutralize HIV-1. Here, we present the crystal structures of the Fabs of human mAb 2909 and macaque mAb 2.5B. Both mAbs have long beta hairpin CDR H3 regions &gt;20 A in length that are each situated at the center of their respective antigen-binding sites. Computational analysis showed that the paratopes include the whole CDR H3, while additional CDR residues form shallow binding pockets. Structural modeling suggests a way to understand the configuration of QNEs and the antigen-antibody interaction for QNE mAbs. Our data will be useful in designing immunogens that may elicit potent neutralizing QNE Abs.
-{{STRUCTURE_3q6f|  PDB=3q6f  |  SCENE=  }}
+Structural Analysis of Human and Macaque mAbs 2909 and 2.5B: Implications for the Configuration of the Quaternary Neutralizing Epitope of HIV-1 gp120.,Spurrier B, Sampson JM, Totrov M, Li H, O'Neal T, Williams C, Robinson J, Gorny MK, Zolla-Pazner S, Kong XP Structure. 2011 May 11;19(5):691-9. PMID:21565703<ref>PMID:21565703</ref>
-===Crystal structure of Fab of human mAb 2909 specific for quaternary neutralizing epitope of HIV-1 gp120===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_21565703}}
-==About this Structure==
-[[3q6f]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q6F OCA].
 ==See Also==
 *[[Monoclonal Antibody|Monoclonal Antibody]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:021565703</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Gorny, M K.]]
+[[Category: Gorny, M K]]
-[[Category: Kong, X P.]]
+[[Category: Kong, X P]]
-[[Category: Li, H.]]
+[[Category: Li, H]]
-[[Category: Neal, T O.]]
+[[Category: Neal, T O]]
-[[Category: Robinson, J.]]
+[[Category: Robinson, J]]
-[[Category: Sampson, J.]]
+[[Category: Sampson, J]]
-[[Category: Spurrier, B.]]
+[[Category: Spurrier, B]]
-[[Category: Totrov, M.]]
+[[Category: Totrov, M]]
-[[Category: William, C.]]
+[[Category: William, C]]
-[[Category: Zolla-Pazner, S.]]
+[[Category: Zolla-Pazner, S]]
 [[Category: Igg]]
 [[Category: Immune system]]
 [[Category: Neutralization of hiv-1 viruse]]
 [[Category: Quaternary epitope of hiv-1 gp120]]