3sfd: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:3sfd.png|left|200px]]
+==crystal structure of porcine mitochondrial respiratory complex II bound with oxaloacetate and pentachlorophenol==
+<StructureSection load='3sfd' size='340' side='right' caption='[[3sfd]], [[Resolution|resolution]] 2.61&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3sfd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SFD FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene>, <scene name='pdbligand=PCI:PENTACHLOROPHENOL'>PCI</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zoy|1zoy]], [[1zp0|1zp0]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Succinate_dehydrogenase_(ubiquinone) Succinate dehydrogenase (ubiquinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.1 1.3.5.1] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sfd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sfd RCSB], [http://www.ebi.ac.uk/pdbsum/3sfd PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The mitochondrial respiratory complex II or succinate: ubiquinone oxidoreductase (SQR) is a key membrane complex in both the tricarboxylic acid cycle and aerobic respiration. Five disinfectant compounds were investigated with their potent inhibition effects on the ubiquinone reduction activity of the porcine mitochondrial SQR by enzymatic assay and crystallography. Crystal structure of the SQR bound with thiabendazole (TBZ) reveals a different inhibitor-binding feature at the ubiquinone binding site where a water molecule plays an important role. The obvious inhibitory effect of TBZ based on the biochemical data (IC(50) approximately 100 mumol/L) and the significant structure-based binding affinity calculation ( approximately 94 mumol/L) draw the suspicion of using TBZ as a good disinfectant compound for nematode infections treatment and fruit storage.
-{{STRUCTURE_3sfd|  PDB=3sfd  |  SCENE=  }}
+Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature.,Zhou Q, Zhai Y, Lou J, Liu M, Pang X, Sun F Protein Cell. 2011 Jul;2(7):531-42. Epub 2011 Aug 6. PMID:21822798<ref>PMID:21822798</ref>
-===crystal structure of porcine mitochondrial respiratory complex II bound with oxaloacetate and pentachlorophenol===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_21822798}}
-==About this Structure==
-[[3sfd]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SFD OCA].
 ==See Also==
 *[[Succinate Dehydrogenase|Succinate Dehydrogenase]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:021822798</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Sus scrofa]]
-[[Category: Liu, M.]]
+[[Category: Liu, M]]
-[[Category: Sun, F.]]
+[[Category: Sun, F]]
-[[Category: Zhai, Y J.]]
+[[Category: Zhai, Y J]]
-[[Category: Zhou, Q J.]]
+[[Category: Zhou, Q J]]
 [[Category: Oxidoreductase]]
 [[Category: Succinate]]
 [[Category: Ubiquinone oxidoreductase]]