1na4: Difference between revisions
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[[Image:1na4.gif|left|200px]] | [[Image:1na4.gif|left|200px]] | ||
'''The structure of immature Yellow Fever virus particle''' | {{Structure | ||
|PDB= 1na4 |SIZE=350|CAPTION= <scene name='initialview01'>1na4</scene> | |||
|SITE= | |||
|LIGAND= | |||
|ACTIVITY= | |||
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'''The structure of immature Yellow Fever virus particle''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1NA4 is a [ | 1NA4 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Yellow_fever_virus Yellow fever virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NA4 OCA]. | ||
==Reference== | ==Reference== | ||
Structures of immature flavivirus particles., Zhang Y, Corver J, Chipman PR, Zhang W, Pletnev SV, Sedlak D, Baker TS, Strauss JH, Kuhn RJ, Rossmann MG, EMBO J. 2003 Jun 2;22(11):2604-13. PMID:[http:// | Structures of immature flavivirus particles., Zhang Y, Corver J, Chipman PR, Zhang W, Pletnev SV, Sedlak D, Baker TS, Strauss JH, Kuhn RJ, Rossmann MG, EMBO J. 2003 Jun 2;22(11):2604-13. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12773377 12773377] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Yellow fever virus]] | [[Category: Yellow fever virus]] | ||
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[[Category: yellow fever immature virus]] | [[Category: yellow fever immature virus]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:54:07 2008'' | ||
Revision as of 13:54, 20 March 2008
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The structure of immature Yellow Fever virus particle
OverviewOverview
Structures of prM-containing dengue and yellow fever virus particles were determined to 16 and 25 A resolution, respectively, by cryoelectron microscopy and image reconstruction techniques. The closely similar structures show 60 icosahedrally organized trimeric spikes on the particle surface. Each spike consists of three prM:E heterodimers, where E is an envelope glycoprotein and prM is the precursor to the membrane protein M. The pre-peptide components of the prM proteins in each spike cover the fusion peptides at the distal ends of the E glycoproteins in a manner similar to the organization of the glycoproteins in the alphavirus spikes. Each heterodimer is associated with an E and a prM transmembrane density. These transmembrane densities represent either an EE or prMprM antiparallel coiled coil by which each protein spans the membrane twice, leaving the C-terminus of each protein on the exterior of the viral membrane, consistent with the predicted membrane-spanning domains of the unprocessed polyprotein.
About this StructureAbout this Structure
1NA4 is a Single protein structure of sequence from Yellow fever virus. Full crystallographic information is available from OCA.
ReferenceReference
Structures of immature flavivirus particles., Zhang Y, Corver J, Chipman PR, Zhang W, Pletnev SV, Sedlak D, Baker TS, Strauss JH, Kuhn RJ, Rossmann MG, EMBO J. 2003 Jun 2;22(11):2604-13. PMID:12773377
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