3px9: Difference between revisions

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-[[Image:3px9.png|left|200px]]
+==RTA in complex with N-(furanylmethyl)-7-carbamoyl-pterin==
+<StructureSection load='3px9' size='340' side='right' caption='[[3px9]], [[Resolution|resolution]] 1.89&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3px9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PX9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PX9 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JP3:2-AMINO-N-(FURAN-2-YLMETHYL)-4-OXO-3,4-DIHYDROPTERIDINE-7-CARBOXAMIDE'>JP3</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3px8|3px8]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3px9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3px9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3px9 RCSB], [http://www.ebi.ac.uk/pdbsum/3px9 PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Ricin is a potent toxin found in castor seeds. The A chain, RTA, enzymaticlly depurinates a specific adenosine in ribosomal RNA, inhibiting protein synthesis. Ricin is a known chemical weapons threat having no effective antidote. This makes the discovery of new inhibitors of great importance. We have previously used 6-substituted pterins, such as pteroic acid, as an inhibitor platform with moderate success. We now report the success of 7-carboxy pterin (7CP) as an RTA inhibitor; its binding has been monitored using both kinetic and temperature shift assays and by X-ray crystallography. We also discuss the synthesis of various derivatives of 7CP, and their binding affinity and inhibitory effects, as part of a program to make effective RTA inhibitors.
-{{STRUCTURE_3px9|  PDB=3px9  |  SCENE=  }}
+-Substituted pterins provide a new direction for ricin A chain inhibitors.,Pruet JM, Jasheway KR, Manzano LA, Bai Y, Anslyn EV, Robertus JD Eur J Med Chem. 2011 May 20. PMID:21641093<ref>PMID:21641093</ref>
-===RTA in complex with N-(furanylmethyl)-7-carbamoyl-pterin===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_21641093}}
-==About this Structure==
-[[3px9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ricinus_communis Ricinus communis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PX9 OCA].
 ==See Also==
 *[[Ricin|Ricin]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:021641093</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Ricinus communis]]
-[[Category: Jasheway, K R.]]
+[[Category: Jasheway, K R]]
-[[Category: Robertus, J D.]]
+[[Category: Robertus, J D]]
 [[Category: Hydrolase]]
 [[Category: Hydrolase-inhibitor complex]]