1n7d: Difference between revisions
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[[Image:1n7d.gif|left|200px]] | [[Image:1n7d.gif|left|200px]] | ||
'''Extracellular domain of the LDL receptor''' | {{Structure | ||
|PDB= 1n7d |SIZE=350|CAPTION= <scene name='initialview01'>1n7d</scene>, resolution 3.70Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> and <scene name='pdbligand=KEG:12-TUNGSTOPHOSPHATE'>KEG</scene> | |||
|ACTIVITY= | |||
|GENE= LDLR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |||
}} | |||
'''Extracellular domain of the LDL receptor''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1N7D is a [ | 1N7D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N7D OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the LDL receptor extracellular domain at endosomal pH., Rudenko G, Henry L, Henderson K, Ichtchenko K, Brown MS, Goldstein JL, Deisenhofer J, Science. 2002 Dec 20;298(5602):2353-8. Epub 2002 Nov 29. PMID:[http:// | Structure of the LDL receptor extracellular domain at endosomal pH., Rudenko G, Henry L, Henderson K, Ichtchenko K, Brown MS, Goldstein JL, Deisenhofer J, Science. 2002 Dec 20;298(5602):2353-8. Epub 2002 Nov 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12459547 12459547] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: ldl-receptor]] | [[Category: ldl-receptor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:53:04 2008'' | ||
Revision as of 13:53, 20 March 2008
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| , resolution 3.70Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | and | ||||||
| Gene: | LDLR (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Extracellular domain of the LDL receptor
OverviewOverview
The low-density lipoprotein receptor mediates cholesterol homeostasis through endocytosis of lipoproteins. It discharges its ligand in the endosome at pH < 6. In the crystal structure at pH = 5.3, the ligand-binding domain (modules R2 to R7) folds back as an arc over the epidermal growth factor precursor homology domain (the modules A, B, beta propeller, and C). The modules R4 and R5, which are critical for lipoprotein binding, associate with the beta propeller via their calcium-binding loop. We propose a mechanism for lipoprotein release in the endosome whereby the beta propeller functions as an alternate substrate for the ligand-binding domain, binding in a calcium-dependent way and promoting lipoprotein release.
DiseaseDisease
Known disease associated with this structure: Hypercholesterolemia, familial OMIM:[606945]
About this StructureAbout this Structure
1N7D is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Structure of the LDL receptor extracellular domain at endosomal pH., Rudenko G, Henry L, Henderson K, Ichtchenko K, Brown MS, Goldstein JL, Deisenhofer J, Science. 2002 Dec 20;298(5602):2353-8. Epub 2002 Nov 29. PMID:12459547
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