1n3n: Difference between revisions

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, resolution 3.0Å

Ligands:

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Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db

OverviewOverview

The decameric peptide SALQNAASIA from the Mycobacterium bovis heat shock protein (hsp) 60 is recognized by the murine T-cell receptor UZ-3-4 in complex with the murine class I major histocompatibility complex molecule H-2D(b). This T-cell receptor cross-reacts with the H-2D(b)-bound non-homologous decameric peptide KDIGNIISDA from the murine hsp60, but does not recognize the nonameric mycobacterial peptide SALQNAASI. Cross-recognition of the KDIGNIISDA/H-2D(b) complex induces autoimmune pathology in immunodeficient mice. We solved the X-ray crystal structure of the SALQNAASIA/H-2D(b) complex at 3.0 A resolution, and we modelled the KDIGNIISDA and SALQNAASI peptides in the H-2D(b) binding site. The structural analysis of the H-2D(b)-bound hsp60 epitopes offers insight into T-cell receptor cross-reactivity.

About this StructureAbout this Structure

1N3N is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Structural analysis of mycobacterial and murine hsp60 epitopes in complex with the class I MHC molecule H-2Db., Ciatto C, Capitani G, Tissot AC, Pecorari F, Pluckthun A, Grutter MG, FEBS Lett. 2003 May 22;543(1-3):11-5. PMID:12753896

Page seeded by OCA on Thu Mar 20 12:51:41 2008

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OCA

@@ Line 1: / Line 1: @@
-[[Image:1n3n.gif|left|200px]]<br /><applet load="1n3n" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1n3n.gif|left|200px]]
-caption="1n3n, resolution 3.0&Aring;" />
-'''Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db'''<br />
+ {{Structure
+|PDB= 1n3n |SIZE=350|CAPTION= <scene name='initialview01'>1n3n</scene>, resolution 3.0&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-N3N is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3N OCA].
+N3N is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N3N OCA].
 ==Reference==
-Structural analysis of mycobacterial and murine hsp60 epitopes in complex with the class I MHC molecule H-2Db., Ciatto C, Capitani G, Tissot AC, Pecorari F, Pluckthun A, Grutter MG, FEBS Lett. 2003 May 22;543(1-3):11-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12753896 12753896]
+Structural analysis of mycobacterial and murine hsp60 epitopes in complex with the class I MHC molecule H-2Db., Ciatto C, Capitani G, Tissot AC, Pecorari F, Pluckthun A, Grutter MG, FEBS Lett. 2003 May 22;543(1-3):11-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12753896 12753896]
 [[Category: Mus musculus]]
 [[Category: Protein complex]]
@@ Line 22: / Line 31: @@
 [[Category: immunoglobulin fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:01:53 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:51:41 2008''