1n1f: Difference between revisions

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File:1n1f.jpg

, resolution 1.95Å

Ligands:

Coordinates:

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Crystal Structure of Human Interleukin-19

OverviewOverview

Interleukin-19 (IL-19) is a novel cytokine that was initially identified during a sequence data base search aimed at finding potential IL-10 homologs. IL-19 shares a receptor complex with IL-20, indicating that the biological activities of these two cytokines overlap and that both may play an important role in regulating development and proper functioning of the skin. We determined the crystal structure of human recombinant IL-19 and refined it at 1.95-A resolution to an R-factor of 0.157. Unlike IL-10, which forms an intercalated dimer, the molecule of IL-19 is a monomer made of seven amphipathic helices, A-G, creating a unique helical bundle. On the basis of the observed structure, we propose that IL-19, IL-20, and other putative members of the proposed IL-10 family together form a distinct subfamily of helical cytokines.

About this StructureAbout this Structure

1N1F is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of interleukin-19 defines a new subfamily of helical cytokines., Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, Wlodawer A, Zdanov A, J Biol Chem. 2003 Jan 31;278(5):3308-13. Epub 2002 Oct 25. PMID:12403790

Page seeded by OCA on Thu Mar 20 12:50:51 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1n1f.jpg|left|200px]]<br /><applet load="1n1f" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1n1f.jpg|left|200px]]
-caption="1n1f, resolution 1.95&Aring;" />
-'''Crystal Structure of Human Interleukin-19'''<br />
+ {{Structure
+|PDB= 1n1f |SIZE=350|CAPTION= <scene name='initialview01'>1n1f</scene>, resolution 1.95&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''Crystal Structure of Human Interleukin-19'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-N1F is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1F OCA].
+N1F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1F OCA].
 ==Reference==
-Crystal structure of interleukin-19 defines a new subfamily of helical cytokines., Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, Wlodawer A, Zdanov A, J Biol Chem. 2003 Jan 31;278(5):3308-13. Epub 2002 Oct 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12403790 12403790]
+Crystal structure of interleukin-19 defines a new subfamily of helical cytokines., Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, Wlodawer A, Zdanov A, J Biol Chem. 2003 Jan 31;278(5):3308-13. Epub 2002 Oct 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12403790 12403790]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 26: / Line 35: @@
 [[Category: interleukin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:01:12 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:50:51 2008''