2v5y: Difference between revisions
New page: left|200px<br /> <applet load="2v5y" size="450" color="white" frame="true" align="right" spinBox="true" caption="2v5y, resolution 3.10Å" /> '''CRYSTAL STRUCTURE O... |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
2V5Y is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NAG and NA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V5Y OCA]]. | 2V5Y is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with NAG and NA as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V5Y OCA]]. | ||
==Reference== | ==Reference== | ||
Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism., Aricescu AR, Siebold C, Choudhuri K, Chang VT, Lu W, Davis SJ, van der Merwe PA, Jones EY, Science. 2007 Aug 31;317(5842):1217-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17761881 17761881] | Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism., Aricescu AR, Siebold C, Choudhuri K, Chang VT, Lu W, Davis SJ, van der Merwe PA, Jones EY, Science. 2007 Aug 31;317(5842):1217-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17761881 17761881] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein-tyrosine-phosphatase]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Aricescu, A.R.]] | [[Category: Aricescu, A.R.]] | ||
| Line 35: | Line 36: | ||
[[Category: transmembrane]] | [[Category: transmembrane]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 17:50:53 2007'' | ||
Revision as of 18:46, 30 October 2007
|
CRYSTAL STRUCTURE OF THE RECEPTOR PROTEIN TYROSINE PHOSPHATASE MU ECTODOMAIN
OverviewOverview
Cell-cell contacts are fundamental to multicellular organisms and are, subject to exquisite levels of control. Human RPTPmu is a type IIB, receptor protein tyrosine phosphatase that both forms an adhesive contact, itself and is involved in regulating adhesion by dephosphorylating, components of cadherin-catenin complexes. Here we describe a 3.1 angstrom, crystal structure of the RPTPmu ectodomain that forms a homophilic trans, (antiparallel) dimer with an extended and rigid architecture, matching the, dimensions of adherens junctions. Cell surface expression of deletion, constructs induces intercellular spacings that correlate with the, ectodomain length. These data suggest that the RPTPmu ectodomain acts as a, distance gauge and plays a key regulatory function, locking the, phosphatase ... [(full description)]
About this StructureAbout this Structure
2V5Y is a [Single protein] structure of sequence from [Homo sapiens] with NAG and NA as [ligands]. Active as [Protein-tyrosine-phosphatase], with EC number [3.1.3.48]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Structure of a tyrosine phosphatase adhesive interaction reveals a spacer-clamp mechanism., Aricescu AR, Siebold C, Choudhuri K, Chang VT, Lu W, Davis SJ, van der Merwe PA, Jones EY, Science. 2007 Aug 31;317(5842):1217-20. PMID:17761881
Page seeded by OCA on Tue Oct 30 17:50:53 2007
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- Pages with broken file links
- Homo sapiens
- Protein-tyrosine-phosphatase
- Single protein
- Aricescu, A.R.
- Chang, V.T.
- Choudhuri, K.
- Davis, S.J.
- Jones, E.Y.
- Lu, W.
- Merwe, P.A.Van.Der.
- Siebold, C.
- NA
- NAG
- Cell adhesion
- Extracellular region
- Glycoprotein
- Hydrolase
- Immunoglobulin domain
- Membrane
- Protein phosphatase
- Receptor
- Receptor protein tyrosine phosphatase
- Transmembrane