1muj: Difference between revisions
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[[Image:1muj.gif|left|200px]] | [[Image:1muj.gif|left|200px]] | ||
'''Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide''' | {{Structure | ||
|PDB= 1muj |SIZE=350|CAPTION= <scene name='initialview01'>1muj</scene>, resolution 2.15Å | |||
|SITE= | |||
|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> | |||
|ACTIVITY= | |||
|GENE= | |||
}} | |||
'''Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide''' | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
1MUJ is a [ | 1MUJ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MUJ OCA]. | ||
==Reference== | ==Reference== | ||
Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif., Zhu Y, Rudensky AY, Corper AL, Teyton L, Wilson IA, J Mol Biol. 2003 Feb 28;326(4):1157-74. PMID:[http:// | Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif., Zhu Y, Rudensky AY, Corper AL, Teyton L, Wilson IA, J Mol Biol. 2003 Feb 28;326(4):1157-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12589760 12589760] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
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[[Category: peptide]] | [[Category: peptide]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:48:24 2008'' | ||
Revision as of 13:48, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of murine class II MHC I-Ab in complex with a human CLIP peptide
OverviewOverview
Association between the class II major histocompatibility complex (MHC) and the class II invariant chain-associated peptide (CLIP) occurs naturally as an intermediate step in the MHC class II processing pathway. Here, we report the crystal structure of the murine class II MHC molecule I-A(b) in complex with human CLIP at 2.15A resolution. The structure of I-A(b) accounts, via the peptide-binding groove's unique physicochemistry, for the distinct peptide repertoire bound by this allele. CLIP adopts a similar conformation to peptides bound by other I-A alleles, reinforcing the notion that CLIP is presented as a conventional peptide antigen. When compared to the related HLA-DR3/CLIP complex structure, the CLIP peptide displays a slightly different conformation and distinct interaction pattern with residues in I-A(b). In addition, after examining the published sequences of peptides presented by I-A(b), we discuss the possibility of predicting peptide alignment in the I-A(b) binding groove using a simple scoring matrix.
About this StructureAbout this Structure
1MUJ is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif., Zhu Y, Rudensky AY, Corper AL, Teyton L, Wilson IA, J Mol Biol. 2003 Feb 28;326(4):1157-74. PMID:12589760
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