2xgf: Difference between revisions
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[[ | ==Structure of the bacteriophage T4 long tail fibre needle-shaped receptor-binding tip== | ||
<StructureSection load='2xgf' size='340' side='right' caption='[[2xgf]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2xgf]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XGF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XGF FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xgf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xgf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xgf RCSB], [http://www.ebi.ac.uk/pdbsum/2xgf PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Bacteriophages are the most numerous organisms in the biosphere. In spite of their biological significance and the spectrum of potential applications, little high-resolution structural detail is available on their receptor-binding fibers. Here we present the crystal structure of the receptor-binding tip of the bacteriophage T4 long tail fiber, which is highly homologous to the tip of the bacteriophage lambda side tail fibers. This structure reveals an unusual elongated six-stranded antiparallel beta-strand needle domain containing seven iron ions coordinated by histidine residues arranged colinearly along the core of the biological unit. At the end of the tip, the three chains intertwine forming a broader head domain, which contains the putative receptor interaction site. The structure reveals a previously unknown beta-structured fibrous fold, provides insights into the remarkable stability of the fiber, and suggests a framework for mutations to expand or modulate receptor-binding specificity. | |||
Structure of the bacteriophage T4 long tail fiber receptor-binding tip.,Bartual SG, Otero JM, Garcia-Doval C, Llamas-Saiz AL, Kahn R, Fox GC, van Raaij MJ Proc Natl Acad Sci U S A. 2010 Nov 1. PMID:21041684<ref>PMID:21041684</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | |||
< | |||
[[Category: Enterobacteria phage t4]] | [[Category: Enterobacteria phage t4]] | ||
[[Category: Bartual, S G | [[Category: Bartual, S G]] | ||
[[Category: Fox, G C | [[Category: Fox, G C]] | ||
[[Category: Garcia-Doval, C | [[Category: Garcia-Doval, C]] | ||
[[Category: Kahn, R | [[Category: Kahn, R]] | ||
[[Category: Llamas-Saiz, A L | [[Category: Llamas-Saiz, A L]] | ||
[[Category: Otero, J M | [[Category: Otero, J M]] | ||
[[Category: Raaij, M J.van | [[Category: Raaij, M J.van]] | ||
[[Category: Fiber protein]] | [[Category: Fiber protein]] | ||
[[Category: Viral protein]] | [[Category: Viral protein]] | ||