1mpu: Difference between revisions

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Revision as of 13:46, 20 March 2008

File:1mpu.jpg

, resolution 2.5Å

Ligands:

Coordinates:

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Crystal Structure of the free human NKG2D immunoreceptor

OverviewOverview

Engagement of diverse protein ligands (MIC-A/B, ULBP, Rae-1, or H60) by NKG2D immunoreceptors mediates elimination of tumorigenic or virally infected cells by natural killer and T cells. Three previous NKG2D-ligand complex structures show the homodimeric receptor interacting with the monomeric ligands in similar 2:1 complexes, with an equivalent surface on each NKG2D monomer binding intimately to a total of six distinct ligand surfaces. Here, the crystal structure of free human NKG2D and in silico and in vitro alanine-scanning mutagenesis analyses of the complex interfaces indicate that NKG2D recognition degeneracy is not explained by a classical induced-fit mechanism. Rather, the divergent ligands appear to utilize different strategies to interact with structurally conserved elements of the consensus NKG2D binding site.

About this StructureAbout this Structure

1MPU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands., McFarland BJ, Kortemme T, Yu SF, Baker D, Strong RK, Structure. 2003 Apr;11(4):411-22. PMID:12679019

Page seeded by OCA on Thu Mar 20 12:46:36 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1mpu.jpg|left|200px]]<br /><applet load="1mpu" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1mpu.jpg|left|200px]]
-caption="1mpu, resolution 2.5&Aring;" />
-'''Crystal Structure of the free human NKG2D immunoreceptor'''<br />
+ {{Structure
+|PDB= 1mpu |SIZE=350|CAPTION= <scene name='initialview01'>1mpu</scene>, resolution 2.5&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE ION'>PO4</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''Crystal Structure of the free human NKG2D immunoreceptor'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-MPU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PO4:'>PO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPU OCA].
+MPU is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MPU OCA].
 ==Reference==
-Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands., McFarland BJ, Kortemme T, Yu SF, Baker D, Strong RK, Structure. 2003 Apr;11(4):411-22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12679019 12679019]
+Symmetry recognizing asymmetry: analysis of the interactions between the C-type lectin-like immunoreceptor NKG2D and MHC class I-like ligands., McFarland BJ, Kortemme T, Yu SF, Baker D, Strong RK, Structure. 2003 Apr;11(4):411-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12679019 12679019]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 20: / Line 29: @@
 [[Category: c-type lectin-like domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:57:48 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:46:36 2008''