1moz: Difference between revisions

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Revision as of 13:46, 20 March 2008

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, resolution 3.17Å

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ADP-ribosylation factor-like 1 (ARL1) from Saccharomyces cerevisiae

OverviewOverview

Structures were determined by x-ray crystallography for two members of the ADP-ribosylation factor (ARF) family of regulatory GTPases, yeast ARF1 and ARL1, and were compared with previously determined structures of human ARF1 and ARF6. These analyses revealed an overall conserved fold but differences in primary sequence and length, particularly in an N-terminal loop, lead to differences in nucleotide and divalent metal binding. Packing of hydrophobic residues is central to the interplay between the N-terminal alpha-helix, switch I, and the interswitch region, which along with differences in surface electrostatics provide explanations for the different biophysical and biochemical properties of ARF and ARF-like proteins.

About this StructureAbout this Structure

1MOZ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases., Amor JC, Horton JR, Zhu X, Wang Y, Sullards C, Ringe D, Cheng X, Kahn RA, J Biol Chem. 2001 Nov 9;276(45):42477-84. Epub 2001 Sep 4. PMID:11535602

Page seeded by OCA on Thu Mar 20 12:46:17 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1moz.gif|left|200px]]<br /><applet load="1moz" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1moz.gif|left|200px]]
-caption="1moz, resolution 3.17&Aring;" />
-'''ADP-ribosylation factor-like 1 (ARL1) from Saccharomyces cerevisiae'''<br />
+ {{Structure
+|PDB= 1moz |SIZE=350|CAPTION= <scene name='initialview01'>1moz</scene>, resolution 3.17&Aring;
+|SITE=
+|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene>
+|ACTIVITY=
+|GENE=
+}}
+'''ADP-ribosylation factor-like 1 (ARL1) from Saccharomyces cerevisiae'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-MOZ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with <scene name='pdbligand=GDP:'>GDP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MOZ OCA].
+MOZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MOZ OCA].
 ==Reference==
-Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases., Amor JC, Horton JR, Zhu X, Wang Y, Sullards C, Ringe D, Cheng X, Kahn RA, J Biol Chem. 2001 Nov 9;276(45):42477-84. Epub 2001 Sep 4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11535602 11535602]
+Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases., Amor JC, Horton JR, Zhu X, Wang Y, Sullards C, Ringe D, Cheng X, Kahn RA, J Biol Chem. 2001 Nov 9;276(45):42477-84. Epub 2001 Sep 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11535602 11535602]
 [[Category: Saccharomyces cerevisiae]]
 [[Category: Single protein]]
@@ Line 24: / Line 33: @@
 [[Category: gtp-binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:57:31 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:46:17 2008''