3j08: Difference between revisions

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-[[Image:3j08.png|left|200px]]
+==High resolution helical reconstruction of the bacterial p-type ATPase copper transporter CopA==
+<StructureSection load='3j08' size='340' side='right' caption='[[3j08]], [[Resolution|resolution]] 10.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3j08]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J08 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J08 FirstGlance]. <br>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">copA, pacS, AF_0473 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 Archaeoglobus fulgidus])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j08 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j08 RCSB], [http://www.ebi.ac.uk/pdbsum/3j08 PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+CopA uses ATP to pump Cu(+) across cell membranes. X-ray crystallography has defined atomic structures of several related P-type ATPases. We have determined a structure of CopA at 10 A resolution by cryo-electron microscopy of a new crystal form and used computational molecular docking to study the interactions between the N-terminal metal-binding domain (NMBD) and other elements of the molecule. We found that the shorter-chain lipids used to produce these crystals are associated with movements of the cytoplasmic domains, with a novel dimer interface and with disordering of the NMBD, thus offering evidence for the transience of its interaction with the other cytoplasmic domains. Docking identified a binding site that matched the location of the NMBD in our previous structure by cryo-electron microscopy, allowing a more detailed view of its binding configuration and further support for its role in autoinhibition.
-{{STRUCTURE_3j08|  PDB=3j08  |  SCENE=  }}
+The Architecture of CopA from Archeaoglobus fulgidus Studied by Cryo-Electron Microscopy and Computational Docking.,Allen GS, Wu CC, Cardozo T, Stokes DL Structure. 2011 Aug 3. PMID:21820315<ref>PMID:21820315</ref>
-===High resolution helical reconstruction of the bacterial p-type ATPase copper transporter CopA===
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-{{ABSTRACT_PUBMED_21820315}}
-==About this Structure==
-[[3j08]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J08 OCA].
 ==See Also==
 *[[ATPase|ATPase]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:021820315</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Archaeoglobus fulgidus]]
-[[Category: Allen, G S.]]
+[[Category: Allen, G S]]
-[[Category: Cardozo, T.]]
+[[Category: Cardozo, T]]
-[[Category: Stokes, D L.]]
+[[Category: Stokes, D L]]
-[[Category: Wu, C.]]
+[[Category: Wu, C]]
 [[Category: Adenosine triphosphatase]]
 [[Category: Archaeal protein]]