Molecular Playground/ClyA: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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 ==Introduction==
-In progress
+Pore-forming toxins (PFTs) are virulence factors secreted by pathogenic organisms.  These are proteins that form transmembrane channels on target cell membranes.  They cause cell death by making the cell membrane permeable, leading to osmotic imbalance and lysis.  There are two classes of PFTs based on their secondary structure, alpha-PFTs and beta-PFTs.  Cytolysin A (ClyA) is an alpha-PFT and is secreted by ''Salmonella'', ''Shigella'' and ''E. coli'' strains.
 ==About this Structure==
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 ==Research on ClyA at UMass Amherst==
-The Chen Lab, in collaboration with the Heuck lab, recently published a paper on [http://www.jbc.org/content/288/43/31042.short, ClyA] assembly. We use a technique commonly used for nanopore sensing called electrophysiology, which allows us to measure the ionic current through the ClyA nanopore.
+The [http://www.chem.umass.edu/~chenlab/index.HTML, Chen Lab] recently published a paper on [http://www.jbc.org/content/288/43/31042.short, ClyA] non-classical assembly. We use a technique commonly used for nanopore sensing called electrophysiology, which allows us to measure the ionic current through the ClyA nanopore.
+Current ClyA projects focus on 3 main areas:
+ClyA non-classical assembly and attack
+ClyA engineered for cancer therapy
+Studies of [http://en.wikipedia.org/wiki/Electro-osmosis, electro-osmosis] using ClyA nanopore
 ==References==