1mjs: Difference between revisions

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Revision as of 13:44, 20 March 2008

File:1mjs.gif

, resolution 1.91Å

Gene:

SMAD3 (Homo sapiens)

Coordinates:

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MH2 domain of transcriptional factor SMAD3

OverviewOverview

Smad3 transduces the signals of TGF-betas, coupling transmembrane receptor kinase activation to transcriptional control. The membrane-associated molecule SARA (Smad Anchor for Receptor Activation) recruits Smad3 for phosphorylation by the receptor kinase. Upon phosphorylation, Smad3 dissociates from SARA and enters the nucleus, in which its transcriptional activity can be repressed by Ski. Here, we show that SARA and Ski recognize specifically the monomeric and trimeric forms of Smad3, respectively. Thus, trimerization of Smad3, induced by phosphorylation, simultaneously activates the TGF-beta signal by driving Smad3 dissociation from SARA and sets up the negative feedback mechanism by Ski. Structural models of the Smad3/SARA/receptor kinase complex and Smad3/Ski complex provide insights into the molecular basis of regulation.

About this StructureAbout this Structure

1MJS is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control., Qin BY, Lam SS, Correia JJ, Lin K, Genes Dev. 2002 Aug 1;16(15):1950-63. PMID:12154125

Page seeded by OCA on Thu Mar 20 12:44:19 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1mjs.gif|left|200px]]<br /><applet load="1mjs" size="350" color="white" frame="true" align="right" spinBox="true"
+[[Image:1mjs.gif|left|200px]]
-caption="1mjs, resolution 1.91&Aring;" />
-'''MH2 domain of transcriptional factor SMAD3'''<br />
+ {{Structure
+|PDB= 1mjs |SIZE=350|CAPTION= <scene name='initialview01'>1mjs</scene>, resolution 1.91&Aring;
+|SITE=
+|LIGAND=
+|ACTIVITY=
+|GENE= SMAD3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+}}
+'''MH2 domain of transcriptional factor SMAD3'''
 ==Overview==
@@ Line 7: / Line 16: @@
 ==About this Structure==
-MJS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MJS OCA].
+MJS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MJS OCA].
 ==Reference==
-Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control., Qin BY, Lam SS, Correia JJ, Lin K, Genes Dev. 2002 Aug 1;16(15):1950-63. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12154125 12154125]
+Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control., Qin BY, Lam SS, Correia JJ, Lin K, Genes Dev. 2002 Aug 1;16(15):1950-63. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12154125 12154125]
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
@@ Line 19: / Line 28: @@
 [[Category: beta sandwich]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:55:51 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 12:44:19 2008''