Molecular Playground/ClyA: Difference between revisions

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Bib Yang, Monifa Fahie, Michal Harel

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 <Structure load='1QOY' size='350' frame='true' align='right' caption='Please select a link from the left to display desired ClyA form' scene='Insert optional scene name here' />
+==Introduction==
 ==About this Structure==
 <scene name='57/571278/Clya_monomer/2'>ClyA monomer in its inactive form</scene>
-[[1QOY]] is a monomer from the dodecameric pore-forming toxin (PFT) from [http://en.wikipedia.org/wiki/Escherichia_coli ''Escherichia coli''] ("E. coli"). It is a 34kDa protein comprised of four alpha helicies, a smaller fifth alpha helix, and a <B><font color="purple">beta tongue</font></B>. The <B><font color="blue">N-terminus</font></B> and the <B><font color="red">C-terminus</font></B> are highlighted. ClyA has been shown to form pores through a non-classical assembly pathway, excreted in oligomeric form in outer-membrane vesicles (OMV) as pre-pores. Only until ClyA reaches the target host membrane does it form the dodecameric PFT with hemolytic activity, possessing the ability to lyse the host cell.
+[[1QOY]] is a 34 kDa monomer from [http://en.wikipedia.org/wiki/Escherichia_coli ''Escherichia coli''] ("E. coli"). It is a pore-forming toxin (PFT) comprised of four alpha helicies, a smaller fifth alpha helix, and a <B><font color="purple">beta tongue</font></B>. The <B><font color="blue">N-terminus</font></B> and the <B><font color="red">C-terminus</font></B> are highlighted. ClyA has been shown to form pores through a non-classical assembly pathway, excreted in oligomeric form in outer-membrane vesicles (OMV) as pre-pores. Only until ClyA reaches the target host membrane does it form the dodecameric PFT with hemolytic activity, possessing the ability to lyse the host cell.
 <scene name='57/571278/Clya_protomer/1'>ClyA protomer</scene>