4ric: Difference between revisions

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-'''Unreleased structure'''
+==FAN1 Nuclease bound to 5' hydroxyl (dT-dT) single flap DNA==
+<StructureSection load='4ric' size='340' side='right' caption='[[4ric]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-The entry 4ric is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ric]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RIC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RIC FirstGlance]. <br>
-Authors: Pavletich, N.P., Wang, R.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ri8|4ri8]], [[4ri9|4ri9]], [[4ria|4ria]], [[4rib|4rib]], [[4rid|4rid]]</td></tr>
-Description: FAN1 Nuclease bond to 5' hydroxyl (dT)2 single flap DNA
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ric FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ric OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ric RCSB], [http://www.ebi.ac.uk/pdbsum/4ric PDBsum]</span></td></tr>
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Karyomegalic interstitial nephritis. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/FAN1_HUMAN FAN1_HUMAN]] Nuclease required for maintenance of chromosomal stability. Plays a key role in DNA repair of DNA interstrand cross-links (ICL) by being recruited to sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, possibly in the resolution of homologous recombination intermediates. Not involved in DNA double-strand breaks resection. Has both endonuclease activity toward 5'-flaps and 5'-exonuclease activity: may act in concert with the 3'-flap-specific enzymes to unhook the ICL by cleaving the lagging-strand template.<ref>PMID:20603015</ref> <ref>PMID:20603016</ref> <ref>PMID:20603073</ref> <ref>PMID:20671156</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Pavletich, N P]]
+[[Category: Wang, R]]
+[[Category: Hydrolase-dna complex]]
+[[Category: Nuclease]]