4ux3: Difference between revisions

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-'''Unreleased structure'''
+==cohesin Smc3-HD:Scc1-N complex from yeast==
+<StructureSection load='4ux3' size='340' side='right' caption='[[4ux3]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ux3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UX3 FirstGlance]. <br>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ux3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ux3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ux3 RCSB], [http://www.ebi.ac.uk/pdbsum/4ux3 PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Through their association with a kleisin subunit (Scc1), cohesin's Smc1 and Smc3 subunits are thought to form tripartite rings that mediate sister chromatid cohesion. Unlike the structure of Smc1/Smc3 and Smc1/Scc1 interfaces, that of Smc3/Scc1 is not known. Disconnection of this interface is thought to release cohesin from chromosomes in a process regulated by acetylation. We show here that the N-terminal domain of yeast Scc1 contains two alpha helices, forming a four-helix bundle with the coiled coil emerging from Smc3's adenosine triphosphatase head. Mutations affecting this interaction compromise cohesin's association with chromosomes. The interface is far from Smc3 residues, whose acetylation prevents cohesin's dissociation from chromosomes. Cohesin complexes holding chromatids together in vivo do indeed have the configuration of hetero-trimeric rings, and sister DNAs are entrapped within these.
-The entry 4ux3 is ON HOLD  until Paper Publication
+Closing the cohesin ring: structure and function of its Smc3-kleisin interface.,Gligoris TG, Scheinost JC, Burmann F, Petela N, Chan KL, Uluocak P, Beckouet F, Gruber S, Nasmyth K, Lowe J Science. 2014 Nov 21;346(6212):963-7. doi: 10.1126/science.1256917. PMID:25414305<ref>PMID:25414305</ref>
-Authors: Gligoris, T.G., Nasmyth, K., Lowe, J.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: cohesin Smc3-HD:Scc1-N complex from yeast
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Gligoris, T G]]
+[[Category: Lowe, J]]
+[[Category: Nasmyth, K]]
+[[Category: Chromosome segregation]]
+[[Category: Cohesin]]
+[[Category: Kleisin]]
+[[Category: Mitosis]]
+[[Category: Protein binding]]
+[[Category: Smc]]