PhoP-PhoQ: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Andrew Brockfield, Alexander Berchansky

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 Two component regulatory systems such as phoP-phoQ are obviously an attractive target for future antimicrobial drugs. If the phoP-phoQ can be altered to a dysfunctional state, the relevant bacteria would have decreased pathogenicity and increased suceptibility to nonspecific immune defense.
 == 3D Structures of  PhoP-PhoQ==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
-===PhoP===
+*PhoP
-[[3r0j]] – MtPhoP – ''Mycobacterium tuberculosis''<br />
+**[[3r0j]] – MtPhoP – ''Mycobacterium tuberculosis''<br />
-[[2pmu]] – MtPhoP DNA-binding domain<br />
+**[[2pmu]] – MtPhoP DNA-binding domain<br />
-[[2pkx]] – EcPhoP regulatory domain (mutant) – ''Escherichia coli''<br />
+**[[2pkx]] – EcPhoP regulatory domain (mutant) – ''Escherichia coli''<br />
-[[2pl1]] - EcPhoP regulatory domain (mutant) + BeF3<br />
+**[[2pl1]] - EcPhoP regulatory domain (mutant) + BeF3<br />
-[[1mvo]] – PhoP N terminal – ''Bacillus subtilis''
+**[[1mvo]] – PhoP N terminal – ''Bacillus subtilis''
-===PhoQ===
+*PhoQ
-[[3cgy]] – StPhoQ catalytic domain + radicicol – ''Salmonella typhimurium''<br />
-[[3cgz]] - StPhoQ catalytic domain<br />
-[[1yax]] - StPhoQ sensor domain (mutant)<br />
-[[3bq8]] – EcPhoQ<br />
-[[3bqa]] – EcPhoQ (mutant)<br />
-[[1id0]] – EcPhoQ kinase domain
+**[[3cgy]] – StPhoQ catalytic domain + radicicol – ''Salmonella typhimurium''<br />
+**[[3cgz]] - StPhoQ catalytic domain<br />
+**[[1yax]] - StPhoQ sensor domain (mutant)<br />
+**[[3bq8]] – EcPhoQ<br />
+**[[3bqa]] – EcPhoQ (mutant)<br />
+**[[1id0]] – EcPhoQ kinase domain
+}}
 ===References===