NF-kB

<StructureSection load='1nfk' size='350' side='right' caption='Structure of mouse NF-kB1 p50 complex with DNA (PDB entry 1nfk)' scene=>

NF-kB or Nuclear Factor NF-kappa is a DNA transcription factor. It is involved in cellular response to stimuli. NF-kB contains a Rel homology domain (RHR) which contains 2 immunoglobulin-like subdomains which interact with the major groove of DNA. There are 5 proteins in the NF-kB family: NF-kB1 (synthesized as p105 and processed to p50), NF-kB2 (synthesized as p100 and processed to p52), RelA (or p65), RelB and cRel. I-κ-B-α is an inhibitor of NF-kB.

3D structures of NF-kappaB3D structures of NF-kappaB

Updated on 01-December-2014

{"openlevels":0}

• RelA (p65)
  • 1bft, 1my5 – mRelA dimerization domain – mouse
    
  • 1my7 – mRelA dimerization domain (mutant)
    
  • 1ram, 2ram – mRelA residues 19-291 + DNA
    
  • 1k3z, 1oy3 – mRelA dimerization domain + I-κ-B-α
    
• NF-kB1 (p50)
  • 1svc – hp50 + DNA - human - NMR
    
  • 1nfk – mp50 + DNA
    
  • 1bfs – mp50 dimerization domain
    
  • 1u36, 1u3j, 1u3y, 1u3z, 1u41, 1u42 – mp50 dimerization domain (mutant)
    
• NF-kB1 (p105)
  • 2dbf – hp105 death domain
    
  • 1ooa – mp105 + RNA
    
• NF-kB1 + RelA
  • 1nfi – hp50 + RelA + I-κ-B-α
    
  • 1ikn – mp50 + RelA + I-κ-B-α
    
  • 1vkx, 1le5, 1le9, 1lei – mp50 + RelA + DNA
    
  • 2i9t – mp105 + RelA + DNA
    
  • 2v2t – mp50 + RelB + DNA
    
  • 2o61 – hp105 RHR domain + RelA + DNA
    
  • 3gut – hp105 + RelA + DNA
    
  • 3jv4 – hp105 dimerization domain + RelB dimerization domain