Macrophage inhibitory factor

<StructureSection load='2ooh' size='350' side='right' caption='Structure of human macrophage inhibitory factor trimer complex with inhibitor, glycerol and sulfate (PDB entry 2ooh)' scene=>

Macrophage inhibitory factor (MIF) is an inflammatory cytokine. MIF is released to the blood stream upon stimulation of white blood cells by bacterial antigens. MIF contains two different catalytic sites. A phenylpyruvate tautomerase site is located in the N terminal. A disulfide reductase site is located in the tetrapeptide Cys-Ala-Leu-Cys in position 57-60.

3D structures of macrophage inhibitory factor3D structures of macrophage inhibitory factor

Updated on 01-December-2014

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• macrophage inhibitory factor
  • 1mif – MIF (mutant) – rat
    
  • 1fim, 1gif, 1gd0, 3djh – hMIF – human
    
  • 1cgq, 1p1g, 4etg, 4eui, 4evg, 4grn, 4gro, 4grp, 4grq, 4grr, 4gru – hMIF (mutant)
    
  • 1mff – mMIF (mutant) – mouse
    
  • 1hfo – MIF – Trichinella spiralis
    
  • 1uiz – MIF – Xenopus laevis
    
  • 2wkb, 2wkf – MIF – Plasmodium berghei
    
  • 3t5s – MIF – Giardia lamblia
    
  • 4gum – MIF (mutant) – rhesus monkey
    
• MIF complexes
  • 1mfi, 2gdg – mMIF + inhibitor
    
  • 1ca7 – hMIF + hydroxyphenylpyruvate
    
  • 3ijj – hMIF + hydroxyphenylpyruvate + inhibitor
    
  • 1gcz, 1ljt, 2ooh, 2oow, 2ooz, 3b9s, 3jsf, 3jsg, 3jtu, 3l5p, 3l5r, 3l5s, 3l5t, 3l5u, 3l5v, 3ijg, 4f2k, 3smb, 3smc, 3wnr, 3wns. 3wnt, 4osf, 4p01 – hMIF + inhibitor
    
  • 3dji – hMIF + tylenol
    
  • 3ce4 – hMIF + PMSF
    
  • 3hof – hMIF + cafeic acid
    
  • 3u18 – hMIF + Chicago sky blue
    
  • 3rf4, 3rf5 – MIF + inhibitor – Ancylostoma ceylanicum