Isopropylmalate dehydrogenase: Difference between revisions
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
*3-isopropylmalate dehydrogenase | |||
[[1ipd]], [[1xaa]], [[1xab]], [[1xac]], [[1xad]], [[1osi]], [[1dpz]], [[1dr0]], [[1dr8]], [[2y3z]] – TtIMDH – ''Thermus thermophilus''<br /> | **[[1ipd]], [[1xaa]], [[1xab]], [[1xac]], [[1xad]], [[1osi]], [[1dpz]], [[1dr0]], [[1dr8]], [[2y3z]] – TtIMDH – ''Thermus thermophilus''<br /> | ||
[[1idm]], [[1osj]], [[1wal]], [[1gc8]], [[1gc9]], [[1g2u]] – TtIMDH (mutant) <br /> | **[[1idm]], [[1osj]], [[1wal]], [[1gc8]], [[1gc9]], [[1g2u]] – TtIMDH (mutant) <br /> | ||
[[2ayq]], [[1v53]] – BcIMDH – ''Bacillus coagulans''<br /> | **[[2ayq]], [[1v53]] – BcIMDH – ''Bacillus coagulans''<br /> | ||
[[1v5b]] – BcIMDH (mutant) <br /> | **[[1v5b]] – BcIMDH (mutant) <br /> | ||
[[1cm7]] – IMDH – ''Escherichia coli''<br /> | **[[1cm7]] – IMDH – ''Escherichia coli''<br /> | ||
[[1vlc]] – IMDH – ''Thermotoga maritima''<br /> | **[[1vlc]] – IMDH – ''Thermotoga maritima''<br /> | ||
[[1v7l]] - IMDH – ''Pyrococcus horikoshii''<br /> | **[[1v7l]] - IMDH – ''Pyrococcus horikoshii''<br /> | ||
[[1w0d]], [[2g4o]] - MtIMDH - ''Mycobacterium tuberculosis''<br /> | **[[1w0d]], [[2g4o]] - MtIMDH - ''Mycobacterium tuberculosis''<br /> | ||
[[3h5e]], [[3h5h]], [[3h5j]] - MtIMDH small subunit<br /> | **[[3h5e]], [[3h5h]], [[3h5j]] - MtIMDH small subunit<br /> | ||
[[2hcu]] – IMDH small subunit – ''Streptococcus mutans''<br /> | **[[2hcu]] – IMDH small subunit – ''Streptococcus mutans''<br /> | ||
[[3q3w]], [[3udo]] - IMDH small subunit – ''Campylobacter jejuni''<br /> | **[[3q3w]], [[3udo]] - IMDH small subunit – ''Campylobacter jejuni''<br /> | ||
[[3r8w]] - IMDH – ''Arabidopsis thaliana''<br /> | **[[3r8w]] - IMDH – ''Arabidopsis thaliana''<br /> | ||
[[3u1h]] - IMDH – ''Bacillus''<br /> | **[[3u1h]] - IMDH – ''Bacillus''<br /> | ||
[[3vml]] - SoIMDH – ''Shewanella oneidensis/Shewanella benthica''<br /> | **[[3vml]] - SoIMDH – ''Shewanella oneidensis/Shewanella benthica''<br /> | ||
*IMDH binary complexes | |||
[[1hex]] – TtIMDH + NAD<BR /> | **[[1hex]] – TtIMDH + NAD<BR /> | ||
[[2y40]] - TtIMDH + Mn<br /> | **[[2y40]] - TtIMDH + Mn<br /> | ||
[[1cnz]] – IMDH + Mn – ''Salmonella typhimurium''<br /> | **[[1cnz]] – IMDH + Mn – ''Salmonella typhimurium''<br /> | ||
[[1wpw]] - IMDH + Mg – ''Sulfolobus tokodaii''<br /> | **[[1wpw]] - IMDH + Mg – ''Sulfolobus tokodaii''<br /> | ||
[[2pkp]] - IMDH small subunit + Zn – ''Methanocaldococcus jannaschii''<br /> | **[[2pkp]] - IMDH small subunit + Zn – ''Methanocaldococcus jannaschii''<br /> | ||
[[4iwh]] - IMDH + Mg – ''Burkholderia thailandensis''<br /> | **[[4iwh]] - IMDH + Mg – ''Burkholderia thailandensis''<br /> | ||
*IMDH ternary complexes | |||
[[2y42]] - TtIMDH + Mn + NAD<BR /> | **[[2y42]] - TtIMDH + Mn + NAD<BR /> | ||
[[2ztw]] - TtIMDH + Mg + inhibitor + NAD<BR /> | **[[2ztw]] - TtIMDH + Mg + inhibitor + NAD<BR /> | ||
[[2y41]] - TtIMDH + 3IPM + Mn<br /> | **[[2y41]] - TtIMDH + 3IPM + Mn<br /> | ||
[[4f7i]] - TtIMDH + Mg + 3IPM + NAD<br /> | **[[4f7i]] - TtIMDH + Mg + 3IPM + NAD<br /> | ||
[[1a05]] – IMDH + 3IPM + Mg - ''Acidithiobacillus ferrooxidans''<br /> | **[[1a05]] – IMDH + 3IPM + Mg - ''Acidithiobacillus ferrooxidans''<br /> | ||
[[3vkz]], [[3vl2]], [[3vl3]], [[3vl4]], [[3vl6]], [[3vl7]] - SoIMDH + 3IPM + Ca <br /> | **[[3vkz]], [[3vl2]], [[3vl3]], [[3vl4]], [[3vl6]], [[3vl7]] - SoIMDH + 3IPM + Ca <br /> | ||
[[3vmj]] - SoIMDH + 3IPM + Mg<br /> | **[[3vmj]] - SoIMDH + 3IPM + Mg<br /> | ||
[[3vmk]] - IMDH + 3IPM + Mg – ''Shewanella bethica'' | **[[3vmk]] - IMDH + 3IPM + Mg – ''Shewanella bethica'' | ||
*2-isopropylmalate dehydrogenase | |||
**[[3fig]] - MtIMDH (mutant) + Zn | |||
}} | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:57, 30 November 2014
Isopropylmalate dehydrogenase (IMDH) catalyzes the oxidative decarboxylation of 3-isopropylmalate (3IPM) to 2-oxo-4-methylvalerate. This reaction is a step in the biosynthesis of leucine in bacteria and fungi. IMDH uses NAD as a cofactor. IMDH is a bifunctional enzyme that catalyzes dehydrogenation and decarboxylation in the presence of NAD and a divalent cation.
3D structures of isopropylmalate dehydrogenase3D structures of isopropylmalate dehydrogenase
Updated on 30-November-2014