Cas9: Difference between revisions

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==3D structures of Cas9==
==3D structures of Cas9==


=== ''Streptococcus pyogenes'' Cas9===
* [[4un3], [[4un4]], and [[4un5]] -  ''S. pyogenes'' Cas9 bound to sgRNA and target DNA
* [[4oo8]]
* [[4oo8]]
* [[4cmp]]
* [[4cmp]]

Revision as of 06:46, 28 November 2014

Cas9 is the RNA-guided DNA endonuclease used by the CRISPR-associated systems to generate double-strand DNA breaks in the invading DNA during an adaptive bacterial immune response.

It has been exploited for use in genome editing systems.

Articles in Proteopedia concerning Cas9 include:

  • any?

3D structures of Cas93D structures of Cas9

  • [[4un3], 4un4, and 4un5 - S. pyogenes Cas9 bound to sgRNA and target DNA
  • 4oo8
  • 4cmp
  • 4cmq - Mn2+-bound S. pyogenes Cas9

Actinomyces naeslundii Cas9Actinomyces naeslundii Cas9

  • 4oge
  • 4ogc - Mn2+-bound A.s naeslundii Cas9

See AlsoSee Also

HNH endonuclease


ReferencesReferences

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur, Joel L. Sussman, Karsten Theis, Michal Harel, Thomas Gastineau, Ann Taylor